Garcia Paulo A, Neal Robert E, Rossmeisl John H, Davalos Rafael V
Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences, Blacksburg, VA 24061, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:2743-6. doi: 10.1109/IEMBS.2010.5626371.
Non-thermal irreversible electroporation (N-TIRE) is a new minimally invasive technique to kill undesirable tissue. We build on our previous intracranial studies in order to evaluate the possibility of using N-TIRE for deep intracranial disorders. In this manuscript we describe a minimally invasive computed tomography (CT) guided N-TIRE procedure in white matter. In addition, we report the electric field threshold needed for white matter ablation (630 - 875 V/cm) using four sets of twenty 50 µs pulses at a voltage-to-distance ratio of 1000 V/cm. We also confirm the non-thermal aspect of the technique with real time temperature data measured at the electrode-tissue interface.
非热不可逆电穿孔（N-TIRE）是一种用于杀死不良组织的新型微创技术。我们基于之前的颅内研究，以评估将N-TIRE用于深部颅内疾病的可能性。在本手稿中，我们描述了一种在白质中进行的微创计算机断层扫描（CT）引导下的N-TIRE手术。此外，我们报告了在电压与距离之比为1000 V/cm的情况下，使用四组每组二十个50微秒脉冲进行白质消融所需的电场阈值（630 - 875 V/cm）。我们还通过在电极-组织界面测量的实时温度数据证实了该技术的非热特性。
