不可逆电穿孔用于颅内手术的初步研究。
Pilot study of irreversible electroporation for intracranial surgery.
作者信息
Garcia Paulo A, Rossmeisl John H, Robertson John, Ellis Thomas L, Davalos Rafael V
机构信息
Virginia Tech-Wake Forest University School of Biomedical Engineering and Sciences, Blacksburg, VA 24061, USA.
出版信息
Annu Int Conf IEEE Eng Med Biol Soc. 2009;2009:6513-6. doi: 10.1109/IEMBS.2009.5333141.
Irreversible electroporation (IRE) is a new minimally invasive technique to treat cancer using intense but short electric pulses. This technique is unique because of its non-thermal mechanism of tissue ablation. Furthermore it can be predicted with numerical models and can be confirmed with ultrasound and MRI. We present some preliminary results on the safety of using irreversible electroporation for canine brain surgery. We also present the electric field (460 V/cm - 560 V/cm) necessary for focal ablation of canine brain tissue and provide some guidelines for treatment planning and execution. This preliminary study is the first step towards using irreversible electroporation as a brain cancer treatment.
不可逆电穿孔（IRE）是一种使用高强度但持续时间短的电脉冲治疗癌症的新型微创技术。该技术因其非热组织消融机制而独具特色。此外，它可以通过数值模型进行预测，并可通过超声和磁共振成像（MRI）加以证实。我们展示了关于在犬类脑部手术中使用不可逆电穿孔安全性的一些初步结果。我们还给出了犬类脑组织局灶性消融所需的电场（460伏/厘米 - 560伏/厘米），并为治疗规划和实施提供了一些指导原则。这项初步研究是将不可逆电穿孔用作脑癌治疗的第一步。
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