Yang Fan, Tu Jie, Yang Dazhi, Li Guanglin, Cai Lintao, Wang Liping
Neuroscience Research Center, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences, 518055 China.
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:823-6. doi: 10.1109/IEMBS.2010.5626774.
Strontium is a newly developed drug for decreasing risks of hip or vertebral fractures in postmenopausal women. Experimental studies have suggested that Strontium could enhance new bone formation and decrease the bone resorption. Mesenchymal stem cell (MSC) is an important category of stem cells which possess the osteogenic differentiation potential and could be used in the bone and cartilage tissue engineering. Here we investigated the effects of strontium on the osteogenic differentiation process of MSC. We found that strontium could enhance the calcium deposition process and promote bone repair, through enhancing the osteogenic differentiation of MSC. This study could help to develop a new strategy to induce the MSC to differentiate into the osteogenic lineage.
锶是一种新开发的用于降低绝经后女性髋部或椎体骨折风险的药物。实验研究表明，锶可以促进新骨形成并减少骨吸收。间充质干细胞（MSC）是一类重要的干细胞，具有成骨分化潜能，可用于骨和软骨组织工程。在此，我们研究了锶对MSC成骨分化过程的影响。我们发现，锶可以通过增强MSC的成骨分化来促进钙沉积过程并促进骨修复。这项研究有助于开发一种诱导MSC分化为成骨谱系的新策略。
