Johnson D G, Waldron M J, Frisina R D, Borkholder D A
Rochester Institute of Technology, Rochester, NY 14623, USA.
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:6441-4. doi: 10.1109/IEMBS.2010.5627335.
Due to the very small size of the mouse inner ear, 600 nL volume, developing effective, controlled infusion systems is quite challenging. Key technologies have been created to minimize both size and power for an implantable pump for murine intracochlear infusions. A method for coupling fine capillary tubing to microfluidic channels is presented which provides low volume, biocompatible interconnects withstanding pressures as high as 827 kPa (120 psi) and consuming less than 20 nL of volume exiting in-plane with the pump. Surface micromachined resistive bridges integrated into the flow channel for anemometry based flow rate measurement have been optimized for low power operation in the ultra-low flow rate regime. A process for creation of deformable diaphragms over pump chambers with simultaneous coating of the microfluidic channels has been developed allowing integration of a biocompatible fluid flow path. These advances represent enabling capabilities for a drug delivery system suitable for space constrained applications such as subcutaneous implantation in mice.
由于小鼠内耳尺寸非常小，体积为600纳升，开发有效、可控的输注系统极具挑战性。已研发出关键技术，以减小用于小鼠耳蜗内输注的植入式泵的尺寸并降低功耗。本文介绍了一种将细毛细管与微流体通道耦合的方法，该方法可提供低体积、生物相容性的互连，承受高达827千帕（120磅力/平方英寸）的压力，且泵平面外流出的体积消耗小于20纳升。集成到流动通道中用于基于风速计的流速测量的表面微机械电阻式电桥已针对超低流速状态下的低功耗运行进行了优化。已开发出一种在泵腔上方制造可变形隔膜并同时对微流体通道进行涂层的工艺，从而实现生物相容性流体流动路径的集成。这些进展为适用于空间受限应用（如小鼠皮下植入）的药物输送系统提供了可行的能力。
