Implantable drug-delivery pumps are being developed to provide the external control of delivery rate or to deliver volumes of drug that are beyond the capabilities of conventional controlled-release formulations. The delivery of insulin to diabetics and chemotherapeutic agents to cancer patients represents the two major applications of such devices, but other applications (chronic pain control, Alzheimer's disease, spasticity, etc.) exist or have been proposed. The most popular device is the Infusaid which is driven by a fluorocarbon vapor-liquid mixture to provide a constant delivery rate. Implantable peristaltic pumps have recently been developed to deliver drugs at variable rates according to a physician-preprogrammed schedule which is actuated with the aid of transcutaneous telemetry. Other devices are available in the literature, if not yet in clinical application.
可植入式药物输送泵正在研发中,以实现对给药速率的外部控制,或输送常规控释制剂无法实现的药物剂量。向糖尿病患者输送胰岛素以及向癌症患者输送化疗药物是此类装置的两个主要应用,但其他应用(慢性疼痛控制、阿尔茨海默病、痉挛等)也已存在或被提出。最常用的装置是英福赛德(Infusaid),它由碳氟化合物气液混合物驱动,以提供恒定的给药速率。最近已研发出可植入式蠕动泵,可根据医生预先设定的程序以可变速率给药,该程序借助经皮遥测启动。文献中还有其他装置,只是尚未应用于临床。