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植入式泵

Implantable pumps.

作者信息

Sefton M V

出版信息

Crit Rev Biomed Eng. 1987;14(3):201-40.

PMID:3297487
Abstract

Implantable drug-delivery pumps are being developed to provide the external control of delivery rate or to deliver volumes of drug that are beyond the capabilities of conventional controlled-release formulations. The delivery of insulin to diabetics and chemotherapeutic agents to cancer patients represents the two major applications of such devices, but other applications (chronic pain control, Alzheimer's disease, spasticity, etc.) exist or have been proposed. The most popular device is the Infusaid which is driven by a fluorocarbon vapor-liquid mixture to provide a constant delivery rate. Implantable peristaltic pumps have recently been developed to deliver drugs at variable rates according to a physician-preprogrammed schedule which is actuated with the aid of transcutaneous telemetry. Other devices are available in the literature, if not yet in clinical application.

摘要

可植入式药物输送泵正在研发中,以实现对给药速率的外部控制,或输送常规控释制剂无法实现的药物剂量。向糖尿病患者输送胰岛素以及向癌症患者输送化疗药物是此类装置的两个主要应用,但其他应用(慢性疼痛控制、阿尔茨海默病、痉挛等)也已存在或被提出。最常用的装置是英福赛德(Infusaid),它由碳氟化合物气液混合物驱动,以提供恒定的给药速率。最近已研发出可植入式蠕动泵,可根据医生预先设定的程序以可变速率给药,该程序借助经皮遥测启动。文献中还有其他装置,只是尚未应用于临床。

相似文献

1
Implantable pumps.植入式泵
Crit Rev Biomed Eng. 1987;14(3):201-40.
2
Controlled drug delivery in the treatment of diabetes mellitus.糖尿病治疗中的控释给药
Crit Rev Ther Drug Carrier Syst. 1985;1(3):189-280.
3
High-technology i.v. infusion devices.高科技静脉输液设备。
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6
Regional arterial chemotherapy of liver tumours. I. Performance comparison between a totally implantable pump and a conventional access system.
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7
Patient-controlled analgesic infusion pumps.患者自控镇痛输注泵
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8
Clinical experience in human diabetics with portable and implantable insulin minipumps.便携式和植入式胰岛素微型泵在人类糖尿病患者中的临床经验。
Life Support Syst. 1983 Jan-Mar;1(1):39-49.
9
Stability of cancer chemotherapeutic agents in a totally implanted drug delivery system.
Am J Hosp Pharm. 1982 Aug;39(8):1321-3.
10
Patient-controlled analgesia in chronic pain patients: experience with a new device designed to be used with implanted programmable pumps.慢性疼痛患者的患者自控镇痛:使用一种设计用于与植入式可编程泵配合使用的新设备的经验。
Pain Pract. 2008 May-Jun;8(3):164-70. doi: 10.1111/j.1533-2500.2008.00187.x. Epub 2008 Mar 31.

引用本文的文献

1
Clinical Considerations for Implanted Neurological Devices in Patients Undergoing Hyperbaric Oxygen Therapy: A Case Report and Review of Manufacturer Guidelines.高压氧治疗患者中植入式神经设备的临床注意事项:病例报告和制造商指南回顾。
Int J Environ Res Public Health. 2023 May 1;20(9):5693. doi: 10.3390/ijerph20095693.
2
In-plane biocompatible microfluidic interconnects for implantable microsystems.用于植入式微系统的平面内兼容微流道互连
IEEE Trans Biomed Eng. 2011 Apr;58(4):943-8. doi: 10.1109/TBME.2010.2098031. Epub 2010 Dec 10.
3
Implantable micropump technologies for murine intracochlear infusions.
用于小鼠耳蜗内输注的可植入微型泵技术。
Annu Int Conf IEEE Eng Med Biol Soc. 2010;2010:6441-4. doi: 10.1109/IEMBS.2010.5627335.
4
Recent developments in insulin delivery techniques. Current status and future potential.胰岛素给药技术的最新进展。现状与未来潜力。
Drugs. 1991 Aug;42(2):213-27. doi: 10.2165/00003495-199142020-00004.