Department of Periodontal and Oral Mucosa Diseases, Medical University of Bialystok, Poland.
Adv Med Sci. 2010;55(2):297-307. doi: 10.2478/v10039-010-0048-x.
A comparison of the clinical status and salivary MMP levels after SRP alone or with ozonotherapy in patients with aggressive and chronic periodontitis.
MATERIAL/METHODS: The study was performed in 52 generally healthy subjects with chronic or aggressive periodontitis. Group CP-S consisted of 12 patients with chronic periodontitis, who underwent scaling and root planing (SRP). In group CP-O there were 25 patients with chronic periodontitis who additionaly to SRP underwent ozonotherapy. The same therapy was performed in group AP, containing 15 patients with aggressive periodontitis. Plaque index, approximal plaque index, bleeding on probing, sulcus bleeding index, probing pocket depth and clinical attachment loss were measured at baseline, at two weeks and two months post-therapy. The levels of MMP-1, MMP-8 and MMP-9 were estimated in non-stimulated saliva with an ELISA method.
All the clinical parameters assessed in the study groups were reduced after treatment. SRP with additional ozonotherapy provided an increase in MMP levels in patients with chronic periodontitis and a reduction in MMP levels in patients with aggressive periodontitis.
SRP followed by ozonotherapy does not lead to further improvement in clinical periodontal parameters in patients with AP and CP.
比较单独进行牙周基础治疗（SRP）和牙周基础治疗联合臭氧治疗对侵袭性和慢性牙周炎患者临床状况和唾液中基质金属蛋白酶（MMP）水平的影响。
材料/方法：本研究纳入了 52 名一般健康的慢性或侵袭性牙周炎患者。CP-S 组包括 12 名慢性牙周炎患者，接受了牙周洁治和根面平整术（SRP）；CP-O 组有 25 名慢性牙周炎患者，在接受 SRP 的基础上联合臭氧治疗；AP 组包含 15 名侵袭性牙周炎患者，接受了相同的治疗。在基线、治疗后两周和两个月，测量菌斑指数、近中菌斑指数、探诊出血、龈沟出血指数、探诊深度和临床附着丧失。采用 ELISA 法测定非刺激唾液中 MMP-1、MMP-8 和 MMP-9 的水平。
研究组所有评估的临床参数在治疗后均降低。在慢性牙周炎患者中，SRP 联合臭氧治疗可增加 MMP 水平，而在侵袭性牙周炎患者中则降低 MMP 水平。
在 AP 和 CP 患者中，SRP 后联合臭氧治疗不会进一步改善临床牙周参数。
