Yazdanpanahbahabadi Mohadese, Ghafouri Mojan, Fereidooni Majid, Hosseinkazemi Hamed
Department of Periodontology, Babol University of Medical Sciences, Babol, Mazandran, Iran.
Department of Periodontology, Babol University of Medical Sciences, Babol, Mazandaran, Iran.
Clin Exp Dent Res. 2025 Oct;11(5):e70216. doi: 10.1002/cre2.70216.
Due to ozonated water's antimicrobial and anti-inflammatory properties, it may be used as a supplementary treatment to scaling and root planing (SRP). The present study aimed to evaluate the clinical effectiveness of using ozonated water instead of tap water during the SRP for people with chronic generalized periodontitis.
This randomized clinical trial was conducted on 30 patients with generalized periodontitis Stages I and II, randomly allocated to two groups. Test sites were subjected to ozonated water, and control sites were subjected to tap water. The clinical periodontal parameters were measured at baseline, the 4th, and 8th week of treatment.
Findings showed a significant decrease in periodontal pocket depth (PPD), clinical attachment level (CAL), and gingival index (GI) at both the 4th and the 8th week of treatment in both groups. PPD was further reduced in the test group, but the difference between the two groups was not significant. However, the greater reduction of CAL at the 4th and 8th week (p < 0.001 and p < 0.001, respectively) and also the greater reduction of GI at the 4th week (p = 0.01) was observed in the test group.
Both the test and control groups showed clinical improvement following nonsurgical periodontal therapy. The ozonated water group demonstrated significantly greater reductions in CAL at the 4th and 8th weeks, and in GI at the 4th week. However, the magnitude of these differences was modest and may have limited clinical relevance. Further research is needed to confirm long-term outcomes.
由于臭氧水具有抗菌和抗炎特性，它可作为龈下刮治术和根面平整术（SRP）的辅助治疗方法。本研究旨在评估在SRP治疗慢性广泛性牙周炎患者时，使用臭氧水替代自来水的临床效果。
本随机临床试验对30例I期和II期广泛性牙周炎患者进行，随机分为两组。试验部位使用臭氧水，对照部位使用自来水。在治疗基线、第4周和第8周测量临床牙周参数。
结果显示，两组在治疗第4周和第8周时，牙周袋深度（PPD）、临床附着水平（CAL）和牙龈指数（GI）均显著降低。试验组的PPD进一步降低，但两组之间的差异不显著。然而，试验组在第4周和第8周时CAL的降低幅度更大（分别为p < 0.001和p < 0.001），并且在第4周时GI的降低幅度也更大（p = 0.01）。
试验组和对照组在非手术牙周治疗后均显示出临床改善。臭氧水组在第4周和第8周时CAL的降低幅度显著更大，在第4周时GI的降低幅度也更大。然而，这些差异的程度较小，可能具有有限的临床相关性。需要进一步研究以确认长期结果。
