O'Farrell N, Moi H
Ealing Hospital, London, UK. nigel.o'
Int J STD AIDS. 2010 Sep;21(9):609-10. doi: 10.1258/ijsa.2010.010245.
Donovanosis is a rare sexually transmitted infection now mainly seen in sporadic cases in Papua New Guinea, South Africa, India, Brazil and Australia. The causative organism is Calymmatobacterium granulomatis though a proposal has been put forward that the organism be reclassified as Klebsiella granulomatis comb. nov. The incubation period is approximately 50 days with genital papules developing into ulcers that increase in size. Four types of lesions are described - ulcerogranulomatous, hypertrophic, necrotic and sclerotic. The diagnosis is usually confirmed by microscopic identification of characteristic Donovan bodies on stained tissue smears. More recently, polymerase chain reaction (PCR) methods have been developed. The recommended treatment is azithromycin 1 g weekly until complete healing is achieved.
杜诺凡病是一种罕见的性传播感染疾病，目前主要见于巴布亚新几内亚、南非、印度、巴西和澳大利亚的散发病例。致病病原体是肉芽肿荚膜杆菌，不过有人提议将该病原体重新分类为肉芽肿克雷伯菌（新组合）。潜伏期约为50天，生殖器丘疹会发展成溃疡，且溃疡会逐渐增大。该病有四种类型的病变——溃疡肉芽肿型、肥厚型、坏死型和硬化型。诊断通常通过在染色组织涂片上显微镜识别特征性的杜诺凡小体来确诊。最近，已开发出聚合酶链反应（PCR）方法。推荐的治疗方法是每周服用1克阿奇霉素，直至完全愈合。
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