Månsson F, Camara C, Biai A, Monteiro M, da Silva Z J, Dias F, Alves A, Andersson S, Fenyö E M, Norrgren H, Unemo M
Infectious Diseases Research Unit, Department of Clinical Sciences, Lund University, Malmö, Sweden.
Int J STD AIDS. 2010 Sep;21(9):631-5. doi: 10.1258/ijsa.2010.009584.
The objective was to examine the prevalence of HIV-1, HIV-2 and 10 other sexually transmitted infections (STIs), and to explore the relationship between HIV and those STIs in women attending two sexual health clinics in Bissau, Guinea-Bissau. In all, 711 women with urogenital problems were included. Clinical examination was performed and HIV-1, HIV-2, human T-cell lymphotropic virus (HTLV)-1, HTLV-2 and syphilis were diagnosed by serology. Trichomonas vaginalis was examined using wet mount microscopy. Cervical samples (and swabs from visible ulcers, if present) were used for polymerase chain reaction (PCR) diagnosis of Chlamydia trachomatis, Mycoplasma genitalium, Haemophilus ducreyi, herpes simplex virus (HSV)-1 and HSV-2, and culture diagnosis of Neisseria gonorrhoeae. The prevalence of HIV-1, HIV-2, and HIV-1 and HIV-2 (dual infection) was 9.5%, 1.8% and 1.1%, respectively. The prevalence of HTLV-1 was 2.8%, HTLV-2 0%, HSV-1 1.4%, HSV-2 7.7%, T. vaginalis 20.4%, syphilis 1.0%, N. gonorrhoeae 1.3%, H. ducreyi 2.7%, M. genitalium 7.7% and C. trachomatis 12.6%. HIV-1 and/or HIV-2 infection was significantly associated with active HSV-2 and HIV-1 was significantly associated with M. genitalium infection. In conclusion, HIV-1 and HIV-2 prevalence was higher compared with previous studies of pregnant women in Guinea-Bissau. The prevalence of co-infection of HIV and other STIs is high. National evidence-based guidelines for the management of STIs in Guinea-Bissau are essential.
目的是调查几内亚比绍比绍市两家性健康诊所就诊女性中HIV-1、HIV-2及其他10种性传播感染（STIs）的流行情况，并探讨HIV与这些性传播感染之间的关系。总共纳入了711名有泌尿生殖系统问题的女性。进行了临床检查，并通过血清学诊断HIV-1、HIV-2、人类嗜T淋巴细胞病毒（HTLV）-1、HTLV-2和梅毒。使用湿片显微镜检查阴道毛滴虫。宫颈样本（以及可见溃疡处的拭子，如有）用于沙眼衣原体、生殖支原体、杜克雷嗜血杆菌、单纯疱疹病毒（HSV）-1和HSV-2的聚合酶链反应（PCR）诊断，以及淋病奈瑟菌的培养诊断。HIV-1、HIV-2以及HIV-1和HIV-2（双重感染）的流行率分别为9.5%、1.8%和1.1%。HTLV-1的流行率为2.8%，HTLV-2为0%，HSV-1为1.4%，HSV-2为7.7%，阴道毛滴虫为20.4%，梅毒为1.0%，淋病奈瑟菌为1.3%，杜克雷嗜血杆菌为2.7%，生殖支原体为7.7%，沙眼衣原体为12.6%。HIV-1和/或HIV-2感染与活动性HSV-2显著相关，HIV-1与生殖支原体感染显著相关。总之，与几内亚比绍此前对孕妇的研究相比，HIV-1和HIV-2的流行率更高。HIV与其他性传播感染的合并感染率很高。几内亚比绍基于证据的全国性传播感染管理指南至关重要。
