Keseler Ingrid M, Collado-Vides Julio, Santos-Zavaleta Alberto, Peralta-Gil Martin, Gama-Castro Socorro, Muñiz-Rascado Luis, Bonavides-Martinez César, Paley Suzanne, Krummenacker Markus, Altman Tomer, Kaipa Pallavi, Spaulding Aaron, Pacheco John, Latendresse Mario, Fulcher Carol, Sarker Malabika, Shearer Alexander G, Mackie Amanda, Paulsen Ian, Gunsalus Robert P, Karp Peter D
SRI International, 333 Ravenswood Ave., Menlo Park, CA 94025, USA.
Nucleic Acids Res. 2011 Jan;39(Database issue):D583-90. doi: 10.1093/nar/gkq1143. Epub 2010 Nov 21.
EcoCyc (http://EcoCyc.org) is a comprehensive model organism database for Escherichia coli K-12 MG1655. From the scientific literature, EcoCyc captures the functions of individual E. coli gene products; their regulation at the transcriptional, post-transcriptional and protein level; and their organization into operons, complexes and pathways. EcoCyc users can search and browse the information in multiple ways. Recent improvements to the EcoCyc Web interface include combined gene/protein pages and a Regulation Summary Diagram displaying a graphical overview of all known regulatory inputs to gene expression and protein activity. The graphical representation of signal transduction pathways has been updated, and the cellular and regulatory overviews were enhanced with new functionality. A specialized undergraduate teaching resource using EcoCyc is being developed.
EcoCyc（http://EcoCyc.org）是一个针对大肠杆菌K-12 MG1655的综合模式生物数据库。EcoCyc从科学文献中获取单个大肠杆菌基因产物的功能；它们在转录、转录后和蛋白质水平的调控；以及它们组成操纵子、复合物和途径的情况。EcoCyc的用户可以通过多种方式搜索和浏览这些信息。EcoCyc网络界面最近的改进包括基因/蛋白质组合页面以及一个调控总结图，该图以图形方式概述了所有已知的基因表达和蛋白质活性调控输入。信号转导途径的图形表示已经更新，并且通过新功能增强了细胞和调控概述。正在开发一种使用EcoCyc的专业本科教学资源。
