University of Utah School of Medicine, Department of Pediatric Critical Care, PO Box 581289, Salt Lake City, UT 84158-1289, USA.
Pediatrics. 2010 Dec;126(6):1156-64. doi: 10.1542/peds.2009-2829. Epub 2010 Nov 22.
The goal was to determine the effect of birth hospital pediatric cardiac specialty center status and neonatal level of care on 90-day mortality for infants with ductal-dependent congenital heart disease.
A population-based, retrospective, cohort study was conducted in Washington State in 1987-2006. All infants born in Washington with gestational ages of ≥32 weeks and birth weights of ≥1500 g who were admitted to a Washington hospital for the care of a congenital cardiac anomaly likely to be ductal dependent were included. Subjects were required to receive a surgical or interventional cardiac procedure within 30 days after birth. Birth certificate data were linked with death certificate data and hospital administrative records. The exposures of interest were birth hospital pediatric cardiac specialty center status and neonatal level of care. The primary outcome was death within 90 days.
A total of 823 infants met the inclusion criteria, 285 born at specialty centers and 538 at other centers. After adjustment for cardiac diagnoses, other congenital anomalies, birth year, maternal income quartile, and definitive-care hospital, there was no significant difference in 90-day mortality for infants born at specialty centers versus other centers (odds ratio: 1.05 [95% confidence interval: 0.65-1.68]).
For infants with ductal-dependent congenital heart disease, there was no difference in 90-day mortality for infants born at specialty centers versus other centers in the state of Washington.
旨在确定出生医院儿科心脏专科中心的地位和新生儿护理水平对患有依赖导管先天性心脏病的婴儿 90 天死亡率的影响。
本研究为 1987-2006 年在华盛顿州进行的一项基于人群的回顾性队列研究。所有在华盛顿州出生、胎龄≥32 周、出生体重≥1500g 的婴儿,如果需要接受可能依赖导管的先天性心脏异常的治疗,将被收入华盛顿州的医院。这些婴儿必须在出生后 30 天内接受手术或介入性心脏手术。出生证明数据与死亡证明数据和医院行政记录相链接。研究的暴露因素是出生医院儿科心脏专科中心的地位和新生儿护理水平。主要结局是 90 天内的死亡。
共有 823 名婴儿符合纳入标准,其中 285 名出生于专科中心,538 名出生于其他中心。在调整了心脏诊断、其他先天性异常、出生年份、产妇收入四分位数和确定性治疗医院后,出生于专科中心的婴儿与出生于其他中心的婴儿在 90 天死亡率方面没有显著差异(优势比:1.05[95%置信区间:0.65-1.68])。
对于患有依赖导管先天性心脏病的婴儿,在华盛顿州,出生于专科中心的婴儿与出生于其他中心的婴儿相比,90 天死亡率没有差异。