Department of Immunology, The University of Texas, M. D. Anderson Cancer Center, Houston, Texas, USA.
Cancer Res. 2010 Dec 1;70(23):9581-90. doi: 10.1158/0008-5472.CAN-10-1379. Epub 2010 Nov 23.
CD4(+)CD25(+)Foxp3(+) T-regulatory cells (Tregs) accumulate in tumors; however, little is known about how the tumor environment influences this process. Here we show that human melanomas express inducible T-cell costimulator ligand (ICOS-L/B7H) that can provide costimulation through ICOS for the expansion of activated Tregs maintaining high Foxp3 and CD25 expression as well as a suppressive function. Thus, ICOS-L expression by melanoma tumor cells may directly drive Treg activation and expansion in the tumor microenvironment as another mechanism of immune evasion.
CD4(+)CD25(+)Foxp3(+) T 调节细胞（Tregs）在肿瘤中积累；然而，人们对肿瘤环境如何影响这一过程知之甚少。在这里，我们表明人类黑色素瘤表达可诱导 T 细胞共刺激配体（ICOS-L/B7H），可通过 ICOS 为激活的 Tregs 的扩增提供共刺激，从而维持高 Foxp3 和 CD25 的表达以及抑制功能。因此，黑色素瘤肿瘤细胞表达的 ICOS-L 可能通过另一种免疫逃逸机制直接驱动肿瘤微环境中 Treg 的激活和扩增。
