Department of Physiology, Tabriz University of Medical Sciences, Tabriz, Iran.
Pharmacol Rep. 2010 Sep-Oct;62(5):910-6. doi: 10.1016/s1734-1140(10)70351-0.
Different pharmacological effects from Nigella sativa have been demonstrated in guinea pig tracheal chains in previous studies. In the present study, the prophylactic effects of thymoquinone on lung pathology as well as blood IL-4 and IFN-γ levels in sensitized guinea pigs were examined. Three groups of guinea pigs sensitized to ovalbumin were given drinking water alone (group S) or drinking water containing low (LTQ) or high (HTQ) concentrations of thymoquinone (groups S + LTQ and S + HTQ). The lung pathology as well as blood IL-4 and IFN-γ levels of the sensitized and the control guinea pigs were evaluated in three sensitized and one control group (n = 8, for all groups). The lungs of the S group showed significant pathological changes (p < 0.001). Blood IL-4 and IFN-γ levels were increased in the sensitized animals compared to those of controls (p < 0.01 and p < 0.001, respectively). Treatment of the S animals with thymoquinone significantly improved their pathological changes to the lung and decreased their IL-4 levels (p < 0.05 to p < 0.001) but increased their IFN-γ levels (p < 0.001). These results showed a preventive effect of thymoquinone on lung inflammation in sensitized guinea pigs.
先前的研究已经证明，黑种草在豚鼠气管链中具有不同的药理作用。在本研究中，研究了百里醌对致敏豚鼠肺病理学以及血液中白细胞介素 4（IL-4）和干扰素 γ（IFN-γ）水平的预防作用。三组卵清蛋白致敏的豚鼠分别给予饮用水（S 组）或含低浓度（LTQ）或高浓度（HTQ）百里醌的饮用水（S+LTQ 和 S+HTQ 组）。在三组致敏组和一组对照组（n = 8，每组）中评估了致敏和对照豚鼠的肺病理学以及血液 IL-4 和 IFN-γ 水平。S 组的肺显示出明显的病理变化（p < 0.001）。与对照组相比，致敏动物的血液 IL-4 和 IFN-γ 水平升高（分别为 p < 0.01 和 p < 0.001）。用百里醌治疗 S 动物可显著改善其肺病理学变化并降低其 IL-4 水平（p < 0.05 至 p < 0.001），但增加其 IFN-γ 水平（p < 0.001）。这些结果表明，百里醌对致敏豚鼠的肺炎症具有预防作用。
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