Noorbakhsh Mohammad-Foad, Shaterzadeh-Yazdi Hanieh, Hayati Farzad, Samarghandian Saeed, Farkhondeh Tahereh
Division of Pharmacology and Toxicology, Department of Basic Sciences, School of Veterinary Medicine, Shiraz University, Shiraz, Iran.
Research Center of Pardis Hospital, Mashhad, Iran.
Tanaffos. 2018 Oct;17(4):211-222.
Lung as vital organ is exposed to many injurious agents that can cause inflammation and oxidative stress, which are potential causes in the pathogenesis of lung diseases. usually introduced as black seed, has been considered for treatment of various diseases and is one the most widely investigated herbs. Thymoquinone (TQ) is the major component of the volatile oil of black seed (54%) which has been indicated to anti-oxidant, anti-inflammatory and anti-neoplastic properties. There is interesting to study on TQ effect as a therapeutic agent for various diseases in both and conditions. In this comprehensive review, we summarized the recent studies related to the effectiveness of TQ on lung disorders such as inflammatory lung diseases, lung fibrosis, asthma and lung cancer. It is concluded that TQ with anti-inflammatory, anti- oxidant, anti-asthmatic and anti- tumor activity can provide therapeutic effects against lung disorders. However, more investigation is needed to produce TQ as a pharmaceutical preparation for human studies.
肺作为重要器官，会接触到许多可导致炎症和氧化应激的有害因子，而炎症和氧化应激是肺部疾病发病机制中的潜在病因。黑种草通常作为黑籽入药，一直被用于治疗各种疾病，是研究最为广泛的草药之一。百里醌（TQ）是黑种草挥发油的主要成分（占54%），已显示出具有抗氧化、抗炎和抗肿瘤特性。研究TQ在体内和体外作为各种疾病治疗剂的效果很有意义。在这篇综述中，我们总结了近期有关TQ对肺部疾病（如炎症性肺病、肺纤维化、哮喘和肺癌）有效性的研究。得出的结论是，具有抗炎、抗氧化、抗哮喘和抗肿瘤活性的TQ可以为肺部疾病提供治疗效果。然而，要将TQ制成供人体研究的药物制剂，还需要更多的研究。
