Department of Ophthalmology, Dongguk University, Ilsan Hospital, Koyang, Kyunggido, South Korea.
Cornea. 2011 May;30(5):600-3. doi: 10.1097/ICO.0b013e3181fb51fb.
To report a case of a corneal papilloma-like lesion associated with human papilloma virus type 6.
A 48-year-old woman presented with a 2-year history of ocular discomfort and gradual visual deterioration in her right eye. Ophthalmic examination revealed an elevated, semitranslucent, well-defined vascularized mass approximately 4 × 2.5 mm in size localized to the right cornea. The surface of the mass appeared smooth and many small, shallow, and irregular elevations were noted.
An excisional biopsy was performed. The underlying cornea was markedly thinned, and fine ramifying vasculature was also noted on the exposed corneal stroma. Typical koilocytic change was observed on the histopathologic examination. Polymerase chain reaction revealed the existence of human papilloma virus type 6 DNA.
Here we describe a case of an isolated corneal papilloma-like lesion. Although the corneal extension of the limbal or the conjunctival papillomas has been commonly observed, an isolated corneal papilloma-like lesion with underlying stromal destruction has only rarely been reported.
报告一例与人类乳头瘤病毒 6 型相关的角膜乳头瘤样病变。
一名 48 岁女性因右眼眼不适和逐渐视力下降 2 年而就诊。眼科检查显示，右眼角膜有一个约 4×2.5mm 大小的隆起、半透明、界限清楚的血管性肿块。肿块表面光滑，有许多小而浅的不规则隆起。
进行了切除活检。下方角膜明显变薄，暴露的角膜基质上也可见细的分支血管。组织病理学检查观察到典型的空泡化改变。聚合酶链反应显示存在人类乳头瘤病毒 6 型 DNA。
我们在此描述一例孤立性角膜乳头瘤样病变。虽然常见的是边缘或结膜乳头瘤的角膜延伸，但仅很少有报道孤立性角膜乳头瘤样病变伴有基质破坏。
