Huang Yi-Ming, Huang Yu-Yun, Yang Hsin-Yu, Tsai Chieh-Chih, Yu Wei-Kuang, Kao Shu-Ching, Kau Hui-Chuan, Liu Catherine Jui-Ling
Department of Ophthalmology, Taipei Veterans General Hospital, Taipei, Taiwan.
Department of Ophthalmology, School of Medicine, National Yang-Ming University, Taipei, Taiwan.
Taiwan J Ophthalmol. 2018 Jan-Mar;8(1):15-18. doi: 10.4103/tjo.tjo_2_18.
The purpose of the study was to evaluate the clinical features, treatment, and outcome of patients with conjunctival papilloma.
Twenty-two patients (22 eyes) with biopsy-proven conjunctival papilloma between January 2005 and January 2015 in a tertiary medical center were retrospectively reviewed. Clinical profiles, treatment, outcome, and factors related to recurrence were evaluated.
There were 16 males (73%) and 6 females (27%), with a mean age of 47 years. The most common location of conjunctival papilloma was the caruncle (43%), followed by palpebral conjunctiva (29%), bulbar conjunctiva (14%), and fornix (14%). Recurrence developed in five patients (22.7%). The risk of postoperative recurrence was significantly related to the presence of bulbar conjunctival papilloma with corneal involvement ( = 0.043) and surgical excision alone ( = 0.039). One case with multiple recurrences developed nonkeratinizing carcinoma. Two young females developed conjunctival papilloma even after receiving human papillomavirus vaccinations.
The recurrence of conjunctival papilloma is not uncommon, especially for those patients underwent surgical excision alone. Surgical excision with adjunctive therapy and long-term follow-up is rational for the treatment of conjunctival papilloma.
本研究旨在评估结膜乳头状瘤患者的临床特征、治疗方法及预后。
回顾性分析2005年1月至2015年1月在一家三级医疗中心经活检证实的22例（22眼）结膜乳头状瘤患者的资料。评估其临床特征、治疗方法、预后及与复发相关的因素。
男性16例（73%），女性6例（27%），平均年龄47岁。结膜乳头状瘤最常见的部位是泪阜（43%），其次是睑结膜（29%）、球结膜（14%）和穹窿部（14%）。5例（22.7%）出现复发。术后复发风险与伴有角膜受累的球结膜乳头状瘤的存在（P = 0.043）及单纯手术切除（P = 0.039）显著相关。1例多次复发患者发展为非角化性癌。2例年轻女性即使接种了人乳头瘤病毒疫苗仍发生结膜乳头状瘤。
结膜乳头状瘤复发并不少见，尤其是对于那些仅接受手术切除的患者。手术切除联合辅助治疗及长期随访是治疗结膜乳头状瘤的合理方法。
