Hamilton Leslie A, Guarascio Anthony J
Department of Clinical Pharmacy and Translational Science, the University of Tennessee Health Science Center College of Pharmacy, Knoxville, TN 37909, USA.
Division of Pharmacy Practice, Duquesne University School of Pharmacy, 600 Forbes Avenue, Pittsburgh, PA 15282, USA.
Pharmacy (Basel). 2019 Aug 3;7(3):104. doi: 10.3390/pharmacy7030104.
Despite the widespread use of tetracycline antibiotics since the late 1940s, tetracycline hypersensitivity reactions have rarely been described in the literature. A comprehensive PubMed search was performed, including allergic and serious adverse reactions attributed to the tetracyclines class of antibiotics. Of the evaluated tetracycline analogs, minocycline was attributed to the greatest overall number and severity of serious adverse events reported in the literature, with notable reactions primarily reported as respiratory and dermatologic in nature. Reactions to tetracycline have also been well described in the literature, and although dermatologic reactions are typically less severe in comparison with minocycline and doxycycline, various reports of anaphylactic reactions exist. Although doxycycline has been noted to have had the fewest reports of severe allergic reactions, rare descriptions of life-threatening reactions are still reported in the literature. Allergic reactions regarding tetracyclines are rare; however, adverse reaction type, severity, and frequency among different tetracycline analogs is somewhat variable. A consideration of hypersensitivity and adverse reaction incidence should be performed prior to the selection of individual tetracycline entities.
自20世纪40年代末以来，尽管四环素类抗生素被广泛使用，但四环素过敏反应在文献中很少被描述。我们进行了全面的PubMed搜索，包括归因于四环素类抗生素的过敏和严重不良反应。在所评估的四环素类似物中，米诺环素在文献中报告的严重不良事件总数和严重程度方面最为突出，主要报告的显著反应为呼吸道和皮肤方面的。四环素的反应在文献中也有充分描述，尽管与米诺环素和多西环素相比，皮肤反应通常不太严重，但也有各种过敏反应的报道。尽管多西环素被认为严重过敏反应的报告最少，但文献中仍有罕见的危及生命反应的描述。四环素类过敏反应很少见；然而，不同四环素类似物之间的不良反应类型、严重程度和频率存在一定差异。在选择个体四环素类药物之前，应考虑过敏反应和不良反应的发生率。
