Büller H A, Grand R J
Department of Pediatrics, Academic Medical Center, Amsterdam, The Netherlands.
Annu Rev Med. 1990;41:141-8. doi: 10.1146/annurev.me.41.020190.001041.
Lactose intolerance is a prevalent clinical problem. Low lactase levels result either from intestinal injury, or as in the majority of the world's adult population, from alterations in the genetic expression of lactase-phlorizin hydrolase. Progress is being made in the basic understanding of the molecular and cellular biology of this enzyme and of the scientific basis of clinical syndromes involving low lactase activity.
乳糖不耐受是一个普遍存在的临床问题。乳糖酶水平低要么是由肠道损伤导致,要么像世界上大多数成年人那样,是由乳糖-根皮苷水解酶基因表达的改变引起。在对这种酶的分子和细胞生物学以及涉及低乳糖酶活性的临床综合征的科学基础的基本理解方面正在取得进展。