去甲肾上腺素能神经元生长模式的区域差异对幼年点燃的影响。

The effect of regional differences in noradrenergic neuron growth patterns on juvenile kindling.

作者信息

Konkol R J, Holmes G L, Thompson J L

机构信息

Department of Neurology, Medical College of Wisconsin, Milwaukee.

出版信息

Brain Res Dev Brain Res. 1990 Mar 1;52(1-2):25-9. doi: 10.1016/0165-3806(90)90218-n.

DOI:10.1016/0165-3806(90)90218-n

PMID:2110041

Abstract

Kindling can be altered by a variety of lesions designed to deplete norepinephrine (NE). However, the effect of the regional alteration in NE concentration on seizure susceptibility has not been studied. Two different concentrations of 6-hydroxydopamine (6-OHDA) were administered to one-day-old rat pups. At age 18 days, rat with significant rostral brain NE loss, due to high dose 6-OHDA, had a faster rate of electrical kindling in the entorhinal cortex than controls. In contrast rats receiving low dose 6-OHDA which resulted in comparable forebrain NE depletion but with a dramatic hindbrain noradrenergic overgrowth showed no enhancement of kindling. These results suggest that in the immature rat the proconvulsant effect of forebrain NE depletion can be overridden by an augmentation of hindbrain NE growth patterns.

摘要

点燃效应可通过多种旨在耗尽去甲肾上腺素（NE）的损伤而改变。然而，NE浓度的区域改变对癫痫易感性的影响尚未得到研究。将两种不同浓度的6-羟基多巴胺（6-OHDA）给予一日龄的幼鼠。在18日龄时，由于高剂量6-OHDA导致显著的脑前部NE丧失的大鼠，其内嗅皮质的电点燃速率比对照组更快。相比之下，接受低剂量6-OHDA的大鼠，其前脑NE耗竭程度相当，但后脑去甲肾上腺素能显著过度生长，点燃效应未增强。这些结果表明，在未成熟大鼠中，前脑NE耗竭的促惊厥作用可被后脑NE生长模式的增强所抵消。