前脑去甲肾上腺素耗竭促进新皮质点燃效应
Facilitation of neocortical kindling by depletion of forebrain noradrenaline.
作者信息
Altman I M, Corcoran M E
出版信息
Brain Res. 1983 Jun 27;270(1):174-7. doi: 10.1016/0006-8993(83)90810-7.
PMID:6409356
Abstract
The role of forebrain noradrenaline in seizures induced by electrical stimulation of the anterior neocortex (kindling) was investigated in control rats and rats pretreated with bilateral injections of 6-hydroxydopamine (6-OHDA) into the mesencephalic trajectory of the dorsal tegmental noradrenergic bundle. Extensive depletion of forebrain noradrenaline significantly facilitated the rate of development of cortico-generalized seizures.
摘要
在对照大鼠和经双侧向背侧被盖去甲肾上腺素能束的中脑轨迹注射6-羟基多巴胺（6-OHDA）预处理的大鼠中，研究了前脑去甲肾上腺素在电刺激前新皮质诱发癫痫（点燃）中的作用。前脑去甲肾上腺素的大量耗竭显著加快了皮质全身性癫痫发作的发展速度。
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