Inai K, Kobuke T, Fujihara M, Yonehara S, Takemoto T, Tsuya T, Yamamoto A, Tachiyama Y, Izumi K, Tokuoka S
Second Department of Pathology, Hiroshima University School of Medicine.
Jpn J Cancer Res. 1990 Feb;81(2):122-8. doi: 10.1111/j.1349-7006.1990.tb02537.x.
To test the tumorigenic potential of aminopyrine, an antipyretic analgesic, it was administered in drinking water at levels of 0 (control), 0.04 and 0.08% to 50 male and 50 female B6C3F1 mice for 100 weeks, and the mice were subsequently maintained without aminopyrine for a further 4 weeks. The most frequent types of tumor, in both treated and control groups, were hepatocellular tumor in male mice and malignant lymphoma/lymphoid leukemia in female mice. No statistically significant differences were observed in the incidences of these tumors between treated and control groups. The incidences of several other tumors in male and female mice also showed no statistically significant differences between treated and control groups. Therefore, no tumorigenic effect of orally administered aminopyrine in B6C3F1 mice was apparent in the present study.
为测试解热镇痛药氨基比林的致瘤潜力，将其以0（对照）、0.04%和0.08%的浓度添加到饮用水中，给50只雄性和50只雌性B6C3F1小鼠饮用100周，随后在不添加氨基比林的情况下继续饲养4周。在治疗组和对照组中，最常见的肿瘤类型，雄性小鼠为肝细胞瘤，雌性小鼠为恶性淋巴瘤/淋巴白血病。治疗组和对照组之间这些肿瘤的发生率没有统计学上的显著差异。雄性和雌性小鼠中其他几种肿瘤的发生率在治疗组和对照组之间也没有统计学上的显著差异。因此，在本研究中，口服氨基比林对B6C3F1小鼠没有明显的致瘤作用。
