用单克隆抗体对韩国分离的恙虫病立克次体进行血清学分类。
Serological classification by monoclonal antibodies of Rickettsia tsutsugamushi isolated in Korea.
作者信息
Chang W H, Kang J S, Lee W K, Choi M S, Lee J H
机构信息
Department of Microbiology, College of Medicine, Seoul National University, Korea.
出版信息
J Clin Microbiol. 1990 Apr;28(4):685-8. doi: 10.1128/jcm.28.4.685-688.1990.
Abstract
Antigenic types of 113 strains of Rickettsia tsutsugamushi isolated from Korean patients were analyzed by using murine polyclonal and monoclonal antibodies. The isolates can be classified in six groups according to their reaction to a panel of monoclonal antibodies. Nine isolates of group I were identified as the Gilliam serotype, and 13 isolates of groups II and III were identified as the Karp serotype. There were two groups that were considered to be a mixture of groups I and II or groups I and III, respectively. The remaining 88 strains of group IV had a unique antigenic determinant that was not present in the prototype strains (Karp, Kato, Gilliam), in addition to sharing common antigens with the prototype strains. Therefore these strains, which are more prevalent in Korea, seem to belong to a new serotype closely related to the Karp serotype.
摘要
利用鼠多克隆抗体和单克隆抗体对从韩国患者分离出的113株恙虫病立克次体的抗原类型进行了分析。根据这些分离株对一组单克隆抗体的反应，可将其分为六组。I组的9株分离株被鉴定为Gilliam血清型，II组和III组的13株分离株被鉴定为Karp血清型。有两组分别被认为是I组和II组或I组和III组的混合。其余88株IV组菌株除与原型菌株（Karp、Kato、Gilliam）共有共同抗原外，还具有原型菌株中不存在的独特抗原决定簇。因此，这些在韩国更为普遍的菌株似乎属于与Karp血清型密切相关的一种新血清型。
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