Turbiak Anjanette J, Kampf Jeff W, Hollis Showalter H D
Department of Medicinal Chemistry, University of Michigan, Ann Arbor, MI 48109, USA.
Tetrahedron Lett. 2010 Mar 3;51(9):1326-1328. doi: 10.1016/j.tetlet.2010.01.007.
An improved synthesis of 3-(substituted)pyrimido[4,5-c]pyridazine-5,7(1H,6H)-diones, a known subclass of 4-deazatoxoflavins, is reported. The approach involves treatment of 3-methyl-6-(1-methylhydrazinyl) uracil with representative phenyl and alkyl glyoxal monohydrates, which in turn are obtained by selenium dioxide oxidation of the corresponding phenyl and alkyl methyl ketones. The first entry into 4-monosubstituted isomers is also reported.
报道了一种已知的4-脱氮氧化黄素亚类——3-（取代）嘧啶并[4,5-c]哒嗪-5,7（1H,6H）-二酮的改进合成方法。该方法包括用代表性的苯基和烷基乙二醛一水合物处理3-甲基-6-（1-甲基肼基）尿嘧啶，而这些苯基和烷基乙二醛一水合物又是通过相应的苯基和烷基甲基酮的二氧化硒氧化得到的。还报道了首次合成4-单取代异构体的方法。
