Division of Gastroenterology, Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea.
Gut Liver. 2010 Sep;4 Suppl 1(Suppl 1):S39-43. doi: 10.5009/gnl.2010.4.S1.S39. Epub 2010 Sep 10.
Photodynamic therapy (PDT) is a promising new modality that utilizes the combination of a photosensitizing chemical and visible light for the management of various solid malignancies, including gastrointestinal (GI) cancer. PDT has some advantages over chemotherapy in terms of its greater safety and lower toxicity in the treatment of malignant lesions. However, PDT has not been used widely for treating upper GI cancer due to its relatively low cost-effectiveness and anatomical characteristics of the GI system. Nevertheless, PDT may be an effective alternative therapy for early upper-GI cancer patients who are at a high risk of curative surgical resection or systemic chemotherapy. In some clinical studies, PDT for various upper GI cancer showed positiveresults. To improve the efficacy of PDT for upper GI cancer, development of photosensitezer and light delivery system is needed.
光动力疗法（PDT）是一种很有前途的新方法，它结合了光敏化学物质和可见光，用于治疗各种实体恶性肿瘤，包括胃肠道（GI）癌症。与化疗相比，PDT 在治疗恶性病变时具有更大的安全性和更低的毒性，这是它的一些优势。然而，由于 PDT 的相对成本效益较低，以及胃肠道系统的解剖学特征，它并未被广泛用于治疗上胃肠道癌。然而，PDT 可能是一种有效的替代疗法，适用于那些高风险接受根治性手术切除或全身化疗的早期上胃肠道癌患者。在一些临床研究中，PDT 治疗各种上胃肠道癌显示出了积极的结果。为了提高 PDT 在上胃肠道癌中的疗效，需要开发光敏剂和光传递系统。
