Lee Han Hee, Choi Myung-Gyu, Hasan Tayyaba
Division of Gastroenterology, Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA.
Korean J Intern Med. 2017 Jan;32(1):1-10. doi: 10.3904/kjim.2016.200. Epub 2017 Jan 1.
Photodynamic therapy (PDT) is a promising therapeutic modality that involves the administration of a photosensitizer followed by local illumination with a specific wavelength of light in the presence of oxygen. PDT is minimally invasive, has high selectivity for cancer, and has good patient compliance due to the simplicity of the procedure; therefore, PDT is widely used as a palliative and salvage treatment in patients with various gastrointestinal malignancies. When used as a salvage treatment for locoregional failures after definitive chemoradiotherapy for esophageal cancer, favorable results have been reported. PDT in conjunction with biliary stenting is a promising palliative treatment for unresectable cholangiocarcinoma, and can be used as an advanced diagnostic and therapeutic strategy in peritoneal dissemination of gastric cancer. Recent clinical reports of PDT for treating non-resectable pancreatic cancer also show promising results. To widen the application of PDT, the integration of PDT with molecular imaging and nanotechnology is being extensively studied. Based on these new developments, PDT is likely to re-emerge as a valuable technique in the treatment of diverse gastrointestinal diseases.
光动力疗法（PDT）是一种很有前景的治疗方式，它包括给予一种光敏剂，然后在有氧气存在的情况下用特定波长的光进行局部照射。PDT微创，对癌症具有高选择性，且由于操作简单，患者依从性良好；因此，PDT被广泛用作各种胃肠道恶性肿瘤患者的姑息性和挽救性治疗。当用于食管癌根治性放化疗后局部区域复发的挽救性治疗时，已报道有良好的效果。PDT联合胆道支架置入术是不可切除胆管癌的一种有前景的姑息性治疗方法，并且可作为胃癌腹膜播散的一种先进的诊断和治疗策略。近期关于PDT治疗不可切除胰腺癌的临床报告也显示出有前景的结果。为了扩大PDT的应用，PDT与分子成像和纳米技术的整合正在被广泛研究。基于这些新进展，PDT可能会再次成为治疗多种胃肠道疾病的一项有价值的技术。
