Department of Medicine, Hallym University College of Medicine, Seoul, Korea.
Gut Liver. 2010 Sep;4 Suppl 1(Suppl 1):S57-61. doi: 10.5009/gnl.2010.4.S1.S57. Epub 2010 Sep 10.
High-intensity focused ultrasound (HIFU) is a novel therapeutic modality that permits noninvasive treatment of various benign and malignant solid tumors, including prostatic cancer, uterine fibroids, hepatic tumors, renal tumors, breast cancers, and pancreatic cancers. Several preclinical and clinical studies have investigated the safety and efficacy of HIFU for treating solid tumors, including pancreatic cancer. The results of nonrandomized studies of HIFU therapy in patients with pancreatic cancer have suggested that HIFU treatment can effectively alleviate cancer-related pain without any significant complications. This noninvasive method of delivering ultrasound energy into the body has recently been evolving from a method for purely thermal ablation to harnessing the mechanical effects of HIFU to induce a systemic immune response and to enhance targeted drug delivery. This review provides a brief overview of HIFU, describes current clinical applications of HIFU for pancreatic cancer, and discusses future applications and challenges.
高强度聚焦超声（HIFU）是一种新型的治疗方式，可实现包括前列腺癌、子宫肌瘤、肝肿瘤、肾肿瘤、乳腺癌和胰腺癌等多种良性和恶性实体肿瘤的非侵入性治疗。多项临床前和临床研究已经调查了 HIFU 治疗实体肿瘤（包括胰腺癌）的安全性和有效性。非随机研究 HIFU 治疗胰腺癌患者的结果表明，HIFU 治疗可以有效缓解癌症相关疼痛，且无明显并发症。这种将超声能量传入体内的无创方法，最近已从单纯的热消融方法发展为利用 HIFU 的机械效应来诱导全身免疫反应和增强靶向药物输送。本文简要概述了 HIFU，描述了 HIFU 治疗胰腺癌的当前临床应用，并讨论了未来的应用和挑战。
