University of Lyon II, Laboratoire Santé-Individu-Société, 5 avenue Pierre Mendès France – Bâtiment K – 69500 Bron, France.
Int J Clin Exp Hypn. 2011 Jan;59(1):27-44. doi: 10.1080/00207144.2011.522874.
This study aimed to characterize the neural networks involved in patients with chronic low-back pain during hypnoanalgesia. PET was performed in 2 states of consciousness, normal alertness and hypnosis. Two groups of patients received direct or indirect analgesic suggestion. The normal alertness state showed activations in a cognitive-sensory pain modulation network, including frontotemporal cortex, insula, somatosensory cortex, and cerebellum. The hypnotic state activated an emotional pain modulation network, including frontotemporal cortex, insula, caudate, accumbens, lenticular nuclei, and anterior cingulate cortex (ACC). Direct suggestion activated cognitive processes via frontal, prefrontal, and orbitofrontal cortices, while indirect suggestion activated a widespread and more emotional network including frontal cortex, anterior insula, inferior parietal lobule, lenticular nucleus, and ACC. Confirmed by visual analog scale data, these results suggest that chronic pain modulation is greater with hypnosis, which enhances both activated networks.
本研究旨在描绘慢性下背痛患者在催眠镇痛时所涉及的神经网络。正电子发射断层扫描（PET）在正常警觉和催眠两种意识状态下进行。两组患者接受直接或间接的镇痛暗示。在正常警觉状态下，激活了一个认知-感觉疼痛调节网络，包括额-颞叶皮质、脑岛、体感皮质和小脑。催眠状态激活了一个情绪疼痛调节网络，包括额-颞叶皮质、脑岛、尾状核、伏隔核、豆状核和前扣带皮层（ACC）。直接暗示通过额叶、前额叶和眶额皮质激活认知过程，而间接暗示则激活了一个更广泛、更情绪化的网络，包括额叶、前脑岛、下顶叶、豆状核和 ACC。通过视觉模拟量表数据证实，这些结果表明，催眠状态下的慢性疼痛调节作用更强，增强了两个激活的网络。
