State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, The Chinese Academy of Sciences, Kunming, PR China.
Planta Med. 2011 May;77(7):754-8. doi: 10.1055/s-0030-1250569. Epub 2010 Nov 23.
Three new terpenoid indole alkaloids, vidolicine (1), normacusine B N-oxide (2), and lochnerine N-oxide (3), together with seven known ones (4-10), were isolated from whole plants of Catharanthus roseus. Their structures were elucidated by spectroscopic methods (NMR, MS, UV, and IR). Cytotoxic activities of these isolates (1-10) were evaluated, but only compound 8 was active against HL-60, SMMC-7721, and A549 cell lines.
从长春花（Catharanthus roseus）全株中分离得到三个新的三萜吲哚生物碱： vidolicine（1）、normacusine B N-氧化物（2）和 lochnerine N-氧化物（3），以及另外七个已知化合物（4-10）。通过光谱方法（NMR、MS、UV 和 IR）阐明了它们的结构。对这些分离物（1-10）进行了细胞毒性活性评价，但只有化合物 8 对 HL-60、SMMC-7721 和 A549 细胞系具有活性。
