长春花中的细胞毒二聚吲哚生物碱。
Cytotoxic dimeric indole alkaloids from Catharanthus roseus.
机构信息
Department of Natural Medicinal Chemistry, China Pharmaceutical University, Nanjing 210009, PR China.
出版信息
Fitoterapia. 2012 Jun;83(4):765-9. doi: 10.1016/j.fitote.2012.03.007. Epub 2012 Mar 13.
PMID:22445552
Abstract
Three new dimeric indole alkaloids (1-3), together with five known ones (4-8), were isolated from the whole plants of Catharanthus roseus. The structures and absolute configurations of new compounds were elucidated by means of NMR and CD analyses. All these compounds were evaluated for their in vitro cytotoxic activities against human breast cancer cell line MDA-MB-231.
摘要
从长春花的全植物中分离得到了三个新的二聚吲哚生物碱（1-3）和五个已知的（4-8）。通过 NMR 和 CD 分析阐明了新化合物的结构和绝对构型。所有这些化合物都评估了它们对人乳腺癌细胞 MDA-MB-231 的体外细胞毒性活性。
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