美登木素 A-G，来自美登木的单萜吲哚生物碱。

Melodinines A-G, monoterpenoid indole alkaloids from Melodinus henryi.

机构信息

State Key Laboratory of Phytochemistry and Plant Resources in West China, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650204, People's Republic of China.

出版信息

J Nat Prod. 2010 Jan;73(1):22-6. doi: 10.1021/np900595v.

DOI:10.1021/np900595v

PMID:20041704

Abstract

Nineteen monoterpenoid indole alkaloids including seven new ones, melodinines A-G (1-7), were isolated from Melodinus henryi. The structures of the new compounds were elucidated using spectroscopic methods, and the structure of compound 4 was confirmed by single-crystal X-ray diffraction analysis. The known compounds were identified by comparing their spectroscopic data with those reported in the literature. All of the compounds were evaluated for cytotoxic activity against five human cancer cell lines, and compound 11 exhibited cytotoxicity against HL-60, SMMC-7721, A-549, and SK-BR-3 cells with IC50 values of 2.0, 16.8, 25.9, and 24.7 microM, respectively.

摘要

从密花轮环藤中分离得到了 19 个单萜吲哚生物碱，包括 7 个新化合物，分别命名为 melodinines A-G（1-7）。采用光谱方法阐明了新化合物的结构，并通过单晶 X 射线衍射分析确定了化合物 4 的结构。通过与文献报道的光谱数据进行比较，鉴定了已知化合物。所有化合物均对五种人癌细胞系进行了细胞毒性活性评价，化合物 11 对 HL-60、SMMC-7721、A-549 和 SK-BR-3 细胞的细胞毒性作用的 IC50 值分别为 2.0、16.8、25.9 和 24.7 μM。