Tekin R, Kiremitçi M, Serbetçi A I, Pişkin E
Chemical Engineering Department, Hacettepe University, Ankara, Turkey.
Biomater Artif Cells Artif Organs. 1990;18(1):95-106. doi: 10.3109/10731199009117291.
The aim of this study is to prepare PHEMA based polymeric membranes for a transdermal delivery system, which includes a skin permeation enhancer (i.e. ethanol) for nitroglycerin. Membranes were prepared by bulk polymerization of HEMA monomer. Polymerization was achieved in the presence of EGDMA, as the cross-linker, and AIBN as the initiator. MMA was used as a comonomer to improve the mechanical properties and to adjust the permeabilities of the resulting membranes. Water was also included in the polymerization mixture to control the matrix structure. Membranes with different chemical and physical structures were prepared. Swelling behaviour of these matrices in ethanol were observed. Nitroglycerin diffusion through swollen membranes (in ethanol) were investigated. It was obtained that the relative amounts of ingredients (i.e., HEMA, MMA, EGDMA and water) in the casting solutions affect both the equilibrium swelling values and the permeabilities. By increasing the water content and by decreasing the amounts of MMA and EGDMA both parameters can be increased. AIBN does not affect these parameters significantly.
本研究的目的是制备用于经皮给药系统的基于聚甲基丙烯酸羟乙酯（PHEMA）的聚合物膜，该系统包含用于硝酸甘油的皮肤渗透促进剂（即乙醇）。通过甲基丙烯酸羟乙酯（HEMA）单体的本体聚合制备膜。在作为交联剂的乙二醇二甲基丙烯酸酯（EGDMA）和作为引发剂的偶氮二异丁腈（AIBN）存在下实现聚合反应。甲基丙烯酸甲酯（MMA）用作共聚单体以改善机械性能并调节所得膜的渗透性。聚合混合物中还包含水以控制基质结构。制备了具有不同化学和物理结构的膜。观察了这些基质在乙醇中的溶胀行为。研究了硝酸甘油在溶胀膜（在乙醇中）中的扩散。结果表明，浇铸溶液中各成分（即HEMA、MMA、EGDMA和水）的相对含量会影响平衡溶胀值和渗透率。通过增加水含量以及减少MMA和EGDMA的量，这两个参数均可提高。AIBN对这些参数没有显著影响。
