Peppas N A, Moynihan H J, Lucht L M
J Biomed Mater Res. 1985 Apr;19(4):397-411. doi: 10.1002/jbm.820190405.
Films were prepared by reaction of HEMA monomer with the crosslinking agent ethyleneglycol dimethacrylate (EGDMA) at crosslinking ratios, X, of 0.005, 0.01, 0.0128, 0.025, and 0.050 mol EGDMA/mol HEMA in the presence of 40 wt.% water at 60 degrees C for 12 h. These membranes were subsequently swollen in water at 37 degrees C and their structure analyzed using a modified Gaussian distribution equation of equilibrium swelling. The calculated values of Mc varied between 800 and 3700 daltons, which corresponded to a correlation length of the mesh size xi of 16.2 to 35.6 A. The structural analysis and diffusive studies of PHEMA membranes indicate that the recent determinations of Mc for PHEMA by Migliaresi et al. (C. Migliaresi, L. Nicodemo, L. Nicolais, and P. Passerini, "Physical characterization of PHEMA gels," J. Biomed. Mater. Res., 15, 307 (1981). and others are not accurate. The methods presented can also be used for analysis of any highly crosslinked polymer network produced by simultaneous polymerization and crosslinking reactions.
通过甲基丙烯酸羟乙酯（HEMA）单体与交联剂乙二醇二甲基丙烯酸酯（EGDMA）在交联比X分别为0.005、0.01、0.0128、0.025和0.050 mol EGDMA/mol HEMA的条件下反应制备薄膜，反应在40 wt.%水存在下于60℃进行12小时。随后将这些膜在37℃的水中溶胀，并使用平衡溶胀的修正高斯分布方程分析其结构。计算得到的Mc值在800至3700道尔顿之间，这对应于网孔尺寸ξ的相关长度为16.2至35.6 Å。聚甲基丙烯酸羟乙酯（PHEMA）膜的结构分析和扩散研究表明，Migliaresi等人（C. Migliaresi、L. Nicodemo、L. Nicolais和P. Passerini，“PHEMA凝胶的物理表征”，《生物医学材料研究杂志》，15，307（1981年））及其他研究人员最近对PHEMA的Mc测定并不准确。所提出的方法也可用于分析通过同时聚合和交联反应产生的任何高度交联的聚合物网络。
