Sun Y M, Huang J J, Lin F C, Lai J Y
Department of Chemical Engineering, Yuan-Ze Institute of Technology, Chung-Li, Taiwan, Republic of China.
Biomaterials. 1997 Apr;18(7):527-33. doi: 10.1016/s0142-9612(96)00166-4.
Composite membranes were prepared by casting a linear poly(2-hydroxyethyl methacrylate) (pHEMA) solution onto polyester non-woven supports, and then the supported pHEMA within the membranes was cross-linked by a diisocyanate cross-linking agent to form a network structure. The swelling and permeation properties of these membranes were evaluated, with a system of nitroglycerin and aqueous ethanol solution, for potential application in transdermal drug delivery. The degree of swelling of these membranes in water and aqueous ethanol decreases as the cross-linker content is increased and increases slightly with an increase in the original molecular weight of the linear pHEMA. The permeation rates of both nitroglycerin and ethanol increase as the cross-linker content is reduced, the polymer molecular weight increases, and the concentration of the casting solution or membrane thickness decreases. Depending on the preparation conditions, the membranes can be tailored to give a permeation flux ranging from 4 to 68 micrograms cm-2 h-1 for nitroglycerin.
通过将线性聚甲基丙烯酸2-羟乙酯（pHEMA）溶液浇铸到聚酯非织造载体上制备复合膜，然后用二异氰酸酯交联剂使膜内负载的pHEMA交联形成网络结构。用硝酸甘油和乙醇水溶液体系评估了这些膜的溶胀和渗透性能，以考察其在透皮给药中的潜在应用。随着交联剂含量的增加，这些膜在水和乙醇水溶液中的溶胀程度降低，并且随着线性pHEMA原始分子量的增加而略有增加。随着交联剂含量的降低、聚合物分子量的增加、浇铸溶液浓度的降低或膜厚度的减小，硝酸甘油和乙醇的渗透速率均增加。根据制备条件，这些膜可以进行调整，使硝酸甘油的渗透通量范围为4至68微克·厘米-2·小时-1。
