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[慢性鼻息肉鼻窦炎患者鼻黏膜纤毛系统的黏液纤毛运输及运动能力]

[Mucociliary transport and motility of the ciliary system of the nasal mucosa in patients with chronic polypous rhinosinusitis].

作者信息

Kozlov V S, Shilenkov V V, Azatian A S, Kramnoĭ A I

出版信息

Vestn Otorinolaringol. 2008(2):10-3.

Abstract

A transport function and motor activity of the ciliary system (MACS) of the nasal mucosa was studied in 10 patients with chronic polypous rhinosinusitis (CPRS). A complex examination included optic endoscopy of the nasal cavity for assessment of nasal polypous process, timing of the saccharine test (ST) according to standard technique, and ciliary beat rate (BR) by V.S. Kozlov method. For estimation of ciliary BR epithelium was taken from five zones: inferior and middle turbinated bones, nasal septum, base and top of the polyp growing from the median nasal passage. ST time in CPRS is much higher (28.3+/-0.34 min) than normal age-specific values. Ciliary BR in different nasal anatomic zones in CPRS is not similar. MACS on the inferior turbinated bone and nasal septum was absent, none of the samples contained cells with functioning cilia. Ciliary BR remained rather high, despite the pathological process, at the site of the top and base of the polyps as well as on the middle turbinated bone (8.7+/-1.07, 8.1+/-1.02, 6.5+/-0.35 Hz, respectively).

摘要

对10例慢性息肉性鼻窦炎(CPRS)患者的鼻黏膜纤毛系统(MACS)的转运功能和运动活性进行了研究。综合检查包括鼻腔光学内镜检查以评估鼻息肉病变、按照标准技术进行糖精试验(ST)计时以及采用V.S.科兹洛夫方法测量纤毛摆动频率(BR)。为评估纤毛BR,从五个区域获取上皮组织:下鼻甲和中鼻甲、鼻中隔、从中鼻道生长的息肉的基部和顶部。CPRS患者的ST时间(28.3±0.34分钟)远高于正常年龄特异性值。CPRS患者不同鼻腔解剖区域的纤毛BR不相同。下鼻甲和鼻中隔上的MACS缺失,所有样本中均未发现具有功能纤毛的细胞。尽管存在病理过程,但息肉顶部和基部以及中鼻甲部位的纤毛BR仍相当高(分别为8.7±1.07、8.1±1.02、6.5±0.35Hz)。

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