Department of Ophthalmology, Copenhagen University Hospital, Roskilde, Denmark.
Acta Ophthalmol. 2012 Aug;90(5):476-80. doi: 10.1111/j.1755-3768.2010.02051.x. Epub 2010 Nov 25.
To investigate the prevalence and clinical characteristics of the Charles Bonnet Syndrome (CBS) in a group of Danish patients with neovascular age-related macular degeneration (AMD) and to study whether CBS is associated with a specific retinal morphology.
Three-hundred consecutive patients with neovascular AMD attending assessment consultations following variable series of ranibizumab therapy were actively asked whether they had symptoms of CBS. If they responded positively, a detailed questionnaire was orally administered to inquire into the details of the symptoms. Detailed optical coherence tomography and autofluorescence was performed. A comparison was made between retinal morphology of a randomly selected equal number of patients without CBS to patients with CBS.
Twenty-five (8.3%) patients of 300 had hallucinations attributable to CBS. The median lesion size - measured as total area with increased autofluorescence - in the CBS group (median 14.2 mm(2)) was not significantly different from the non-CBS group (median 16.2 mm(2)); however, the patients with CBS had significantly larger areas of geographic atrophy (median 2 mm(2)) compared to patients without CBS (median 0.3 mm(2)) (p = 0.002).
CBS is not uncommon in an unselected population with neovascular AMD, and symptoms of CBS may be associated with larger areas of geographic atrophy.
调查一组丹麦新生血管性年龄相关性黄斑变性（AMD）患者中 Charles Bonnet 综合征（CBS）的患病率和临床特征，并研究 CBS 是否与特定的视网膜形态有关。
300 名接受雷珠单抗治疗的新生血管性 AMD 患者连续就诊，主动询问他们是否有 CBS 症状。如果他们回答阳性，将通过口头询问详细问卷以了解症状的详细情况。进行详细的光学相干断层扫描和自发荧光检查。将 CBS 患者与随机选择的数量相等的无 CBS 患者的视网膜形态进行比较。
25 名（8.3%）300 名患者出现归因于 CBS 的幻觉。CBS 组（中位数 14.2mm²）的病变大小（以自发荧光增加的总面积衡量）与非 CBS 组（中位数 16.2mm²）无显著差异；然而，CBS 患者的地图状萎缩面积（中位数 2mm²）明显大于无 CBS 患者（中位数 0.3mm²）（p=0.002）。
在未经选择的新生血管性 AMD 患者人群中，CBS 并不罕见，CBS 症状可能与更大的地图状萎缩面积有关。
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