Leandro João Esteves, Beato João, Pedrosa Ana Catarina, Pinheiro-Costa João, Falcão Manuel, Falcão-Reis Fernando, Carneiro Ângela M
Department of Ophthalmology, São João Hospital, Porto, Portugal.
Department of Surgery and Physiology, Faculty of Medicine, University of Porto, Porto, Portugal.
Invest Ophthalmol Vis Sci. 2017 Aug 1;58(10):4138-4142. doi: 10.1167/iovs.16-21270.
We investigate the prevalence of the Charles Bonnet syndrome (CBS) in patients with neovascular age-related macular degeneration (AMD) and analyze the role of oral proton pump inhibitors (PPIs) and other potential risk factors.
A total of 510 consecutive patients with neovascular-AMD followed at a single tertiary center in Portugal were screened for CBS. Using a structured questionnaire, psychiatrically healthy individuals were interviewed systematically and divided into a CBS group and a non-CBS group. Demographic data, current medication, and ocular risk factors were collected and compared between the two groups.
A total of 500 patients met the inclusion criteria and 471 with complete data were included in the final analysis. The prevalence of CBS was 9.0% (45/500). Using a binary logistic regression model, correlations were found between older age (P = 0.002), PPI intake (P = 0.022), poor visual acuity (P = 0.004), and development of CBS. PPIs doubled the risk of CBS from 7% (20/304) to 15% (25/167), with an odds ratio of 2.154. The increased risk for visual hallucinations caused by PPIs was independent of age (P = 0.598) and visual acuity (P = 0.739).
The prevalence of CBS in neovascular-AMD patients is high and mainly affects older individuals with poor visual acuity. PPIs seem to increase the risk of development of hallucinations independently of the degree of visual loss.
我们调查了新生血管性年龄相关性黄斑变性（AMD）患者中查尔斯·邦尼特综合征（CBS）的患病率，并分析了口服质子泵抑制剂（PPI）及其他潜在危险因素的作用。
对葡萄牙一家三级中心连续随访的510例新生血管性AMD患者进行CBS筛查。通过结构化问卷，对精神健康个体进行系统访谈，并分为CBS组和非CBS组。收集两组的人口统计学数据、当前用药情况及眼部危险因素并进行比较。
共有500例患者符合纳入标准，471例数据完整的患者纳入最终分析。CBS的患病率为9.0%（45/500）。使用二元逻辑回归模型发现，年龄较大（P = 0.002）、服用PPI（P = 0.022）、视力差（P = 0.004）与CBS的发生相关。PPI使CBS的风险从7%（20/304）增加一倍至15%（25/167），比值比为2.154。PPI导致视幻觉风险增加与年龄（P = 0.598）和视力（P = 0.739）无关。
新生血管性AMD患者中CBS的患病率较高，主要影响视力差的老年人。PPI似乎会独立于视力丧失程度增加幻觉发生的风险。
