Division of Matrix Biology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.
Circ Res. 2010 Nov 26;107(11):1304-12. doi: 10.1161/CIRCRESAHA.110.231910.
Cardiac fibroblasts play a critical role in maintenance of normal cardiac function. They are indispensable for damage control and tissue remodeling on myocardial injury and principal mediators of pathological cardiac remodeling and fibrosis. Despite their manyfold functions, cardiac fibroblasts remain poorly characterized in molecular terms. Evidence is evolving that cardiac fibroblasts are a heterogeneous population and likely derive from various distinct tissue niches in health and disease. Here, we review our emerging understanding of where cardiac fibroblasts come from, as well as how we can possibly use this knowledge to develop novel therapies for cardiac fibrosis.
心肌成纤维细胞在维持正常心脏功能方面起着关键作用。它们在心肌损伤时对于损伤控制和组织重塑是不可或缺的，也是病理性心脏重塑和纤维化的主要介质。尽管心肌成纤维细胞具有多种功能，但在分子水平上它们的特征仍描述不足。有证据表明，心肌成纤维细胞是一个异质性群体，可能来源于健康和疾病状态下各种不同的组织龛位。在这里，我们综述了我们对心肌成纤维细胞来源的认识的最新进展，以及我们如何利用这些知识为心脏纤维化开发新的治疗方法。
