Eskola J, Käyhty H, Takala A, Rönnberg P R, Kela E, Peltola H
National Public Health Institute, Helsinki, Finland.
Vaccine. 1990 Apr;8(2):107-10. doi: 10.1016/0264-410x(90)90131-5.
To find a wide spectrum vaccine against bacteraemic disease in childhood, we immunized 293 Finnish children at 24 months of age intramuscularly with different combinations of the currently available vaccines, namely Haemophilus influenzae type b polysaccharide-protein conjugate vaccine (PRP-D) mixed with meningococcal and/or pneumococcal capsular polysaccharide vaccines. All the vaccines were immunogenic. The increase in antibody concentration after vaccinations was not affected by the number of polysaccharide antigens. Although no serious reactions were seen, the frequency of both local and fever reactions was greater in groups that received several vaccine antigens. Halving of the vaccine dose decreased the reactogenicity without impairing the immunogenicity.
为了找到一种针对儿童菌血症性疾病的广谱疫苗，我们对293名24月龄的芬兰儿童进行了肌肉注射，使用了目前可用疫苗的不同组合，即b型流感嗜血杆菌多糖蛋白结合疫苗（PRP-D）与脑膜炎球菌和/或肺炎球菌荚膜多糖疫苗混合。所有疫苗均具有免疫原性。接种疫苗后抗体浓度的增加不受多糖抗原数量的影响。虽然未观察到严重反应，但接受多种疫苗抗原的组中局部反应和发热反应的频率更高。将疫苗剂量减半可降低反应原性，而不损害免疫原性。
