Department of Pharmacology, Toxicology and Clinical Pharmacology, Faculty of Medicine, University of Novi Sad, Hajduk Veljkova 3, 21000 Novi Sad, Serbia.
Eur J Clin Pharmacol. 2011 Feb;67(2):203-7. doi: 10.1007/s00228-010-0951-x. Epub 2010 Nov 24.
To analyze the amount and pattern of use of non-steroidal anti-inflammatory drugs (NSAIDs) in Serbia and to compare these parameters with those in Croatia and Denmark. The prescribing pattern of NSAIDs in Serbia as a direct indicator of physicians' knowledge of these agents was also assessed.
The use of NSAIDs in Serbia, Croatia, and Denmark was analyzed during a 4-year period (2005-2008). Data were retrieved from the annual reports of the Agency for Drugs and Medical Devices of Serbia, Croatia, and Denmark. Data on prescribing behavior were obtained from the Health Insurance Fund of Serbia and represent NSAIDs issued by prescription between 2005 and 2008. Results were expressed as the number of defined daily doses/1000 inhabitants/day. The drug utilization 90% method was also used.
The total consumption of NSAIDs in Serbia was higher than that in Croatia and Denmark. Diclofenac accounted for approximately 50% of NSAID consumption during the observation period, followed (in much smaller quantities) by ibuprofen. The most commonly prescribed medicine was diclofenac, followed, in much smaller amounts, by ibuprofen. There was no trend of a reduced consumption of diclofenac or of an increased use of ibuprofen during the study period
These data suggest that factors other than evidence-based medicine have a dominant effect on the use of NSAIDs in Serbia. Targeted education from independent sources in the prescribing, dispensing, and use of drugs is important to improve the quality of the prescribing behavior and the use of NSAIDs.
分析塞尔维亚非甾体抗炎药（NSAIDs）的用量和使用模式，并将这些参数与克罗地亚和丹麦进行比较。还评估了塞尔维亚 NSAIDs 的处方模式，将其作为医生对这些药物了解程度的直接指标。
在四年期间（2005-2008 年）对塞尔维亚、克罗地亚和丹麦的 NSAIDs 使用情况进行了分析。数据取自塞尔维亚、克罗地亚和丹麦药品和医疗器械管理局的年度报告。处方行为数据取自塞尔维亚健康保险基金，代表 2005 年至 2008 年期间开具的处方 NSAIDs。结果表示为每千名居民每日限定日剂量数。还使用了药物利用 90%方法。
塞尔维亚的 NSAIDs 总消耗量高于克罗地亚和丹麦。双氯芬酸在观察期间占 NSAIDs 消费的近 50%，其次是布洛芬。最常开的药是双氯芬酸，其次是布洛芬，但用量要小得多。在研究期间，双氯芬酸的消耗量没有减少趋势，也没有增加布洛芬的使用趋势。
这些数据表明，在塞尔维亚，除循证医学以外的其他因素对 NSAIDs 的使用有主导影响。来自独立来源的关于药物处方、配药和使用的有针对性的教育对于提高处方行为和 NSAIDs 使用质量很重要。
