Langaas Harald Chr, Hurley Eimir, Dyrkorn Roar, Spigset Olav
Regional Medicines Information and Pharmacovigilance Centre (RELIS), Department of Clinical Pharmacology, St. Olav University Hospital, Trondheim, Norway.
Centre for Health Policy and Management, Trinity College Dublin, Dublin, Ireland.
Eur J Clin Pharmacol. 2019 Apr;75(4):577-586. doi: 10.1007/s00228-018-02611-y. Epub 2018 Dec 31.
The objective of this study was to examine the impact of an academic detailing programme in primary care in Norway on the prescribing rate of diclofenac, naproxen and non-steroidal anti-inflammatory drugs (NSAIDs) in total.
An academic detailing programme was delivered to general practitioners (GPs) in two Norwegian cities. The key message was to avoid diclofenac and COX-2 inhibitors and to use naproxen as the NSAID of choice. We analysed prescription data for 12 months before and after the programme to estimate its impact, using interrupted time series to control for underlying trends, and using the rest of Norway as a comparator. The primary outcome was change in the proportion of the population filling a prescription for diclofenac; secondary outcomes were change in naproxen prescribing and change in total NSAID prescribing.
Controlling for baseline trends, and relative to changes in the rest of Norway, there was a statistically significant reduction in the prescribing rate of diclofenac in both cities (- 18% and - 16%, respectively) immediately after the intervention. The impact of the programme on prescribing of diclofenac was maintained by the end of the 12 month follow-up period. An increase in the prescribing of naproxen was observed in both cities. The programme had no impact on the overall rate of prescribing of NSAIDs.
Academic detailing was effective in changing the choice of prescribed NSAID amongst Norwegian GPs. Academic detailing is potentially an important method for providing GPs with independent, evidence-based updates on pharmacotherapy to improve prescribing.
本研究的目的是检验挪威一项基层医疗学术推广项目对双氯芬酸、萘普生及非甾体抗炎药(NSAIDs)总体处方率的影响。
在挪威的两个城市向全科医生(GPs)开展了一项学术推广项目。关键信息是避免使用双氯芬酸和COX-2抑制剂,并将萘普生作为NSAIDs的首选药物。我们分析了该项目实施前后12个月的处方数据以评估其影响,采用间断时间序列控制潜在趋势,并将挪威其他地区作为对照。主要结局是开具双氯芬酸处方的人群比例的变化;次要结局是萘普生处方的变化及NSAIDs总处方的变化。
控制基线趋势后,与挪威其他地区的变化相比,干预后两个城市双氯芬酸的处方率均有统计学意义的显著下降(分别为-18%和-16%)。在12个月随访期结束时,该项目对双氯芬酸处方的影响得以维持。两个城市均观察到萘普生处方增加。该项目对NSAIDs的总体处方率没有影响。
学术推广有效地改变了挪威全科医生对NSAIDs的处方选择。学术推广可能是向全科医生提供独立、基于证据的药物治疗更新信息以改善处方的重要方法。