精选香料的肿瘤抑制及抗癌活性

Tumour reducing and anticarcinogenic activity of selected spices.

作者信息

Unnikrishnan M C, Kuttan R

机构信息

Amala Cancer Research Centre, Amala Nagar, Kerala, India.

出版信息

Cancer Lett. 1990 May 15;51(1):85-9. doi: 10.1016/0304-3835(90)90235-p.

DOI:10.1016/0304-3835(90)90235-p

PMID:2110862

Abstract

Tumour reducing activity of extracts of eight commonly used spices in India were studied in mice transplanted intraperitoneally with Ehrlich ascites tumour. Oral administration of extracts of black pepper, asafoetida, pippali and garlic could increase the percentage of life span in these mice by 64.7%, 52.9%, 47% and 41.1%, respectively. However intraperitoneal administration of spice extracts did not produce any significant reduction in tumour growth except for sesame (38.8%). Garlic extract and asafoetida extracts also inhibited two stage chemical carcinogenesis induced by 7,12 dimethyl benzanthracene and croton oil on mice skin with significant reduction in papiloma formation. These results indicate the potential use of spices as anti-cancer agents as well as anti-tumour promoters.

摘要

对印度八种常用香料提取物的抑瘤活性进行了研究，将艾氏腹水瘤腹腔移植到小鼠体内。口服黑胡椒、阿魏、荜茇和大蒜提取物可使这些小鼠的寿命延长率分别提高64.7%、52.9%、47%和41.1%。然而，除芝麻（38.8%）外，腹腔注射香料提取物对肿瘤生长没有显著抑制作用。大蒜提取物和阿魏提取物还抑制了7,12-二甲基苯并蒽和巴豆油诱导的小鼠皮肤两阶段化学致癌作用，乳头状瘤形成显著减少。这些结果表明香料有作为抗癌剂和抗肿瘤促进剂的潜在用途。