一种可能用于区分猪带绦虫两种地理基因型的核DNA标记。
A possible nuclear DNA marker to differentiate the two geographic genotypes of Taenia solium tapeworms.
作者信息
Sato Marcello Otake, Sako Yasuhito, Nakao Minoru, Wandra Toni, Nakaya Kazuhiro, Yanagida Tetsuya, Ito Akira
机构信息
Escola de Medicina, Universidade Federal do Tocantins, Palmas, Brazil.
出版信息
Parasitol Int. 2011 Jan;60(1):108-10. doi: 10.1016/j.parint.2010.11.004. Epub 2010 Nov 23.
Cysticercosis caused by infection with embryonated eggs of the pork tapeworm Taenia solium is an important cause of neurological disease worldwide. Based on the phylogenetic analysis of mitochondrial DNA, the pathogen has been divided into two geographic clades, corresponding to Afro-American and Asian genotypes. In this study the genotyping of T. solium was carried out by using the nuclear DNA sequences of the immunodiagnostic antigen genes Ag1V1 and Ag2. The two geographic genotypes were supported by the Ag2 sequences, especially showing unique substitutions in each of the genotypes. It seems likely that the Ag2 may be a novel nuclear DNA marker to distinguish the two geographic genotypes of T. solium.
由猪带绦虫带绦虫卵感染引起的囊尾蚴病是全球神经系统疾病的重要病因。基于线粒体DNA的系统发育分析，该病原体已被分为两个地理分支，分别对应非洲-美洲基因型和亚洲基因型。在本研究中，通过使用免疫诊断抗原基因Ag1V1和Ag2的核DNA序列对猪带绦虫进行基因分型。Ag2序列支持了这两种地理基因型，特别是在每种基因型中都显示出独特的替代。Ag2似乎可能是区分猪带绦虫两种地理基因型的新型核DNA标记。
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