在分别有和没有 HIV 感染的巴西卡波西肉瘤患者的病变组织中，KSHV 基因型 A 和 C 更为常见。
KSHV genotypes A and C are more frequent in Kaposi sarcoma lesions from Brazilian patients with and without HIV infection, respectively.
机构信息
Pathology Department at Botucatu Medical School, Sao Paulo State University, Brazil.
出版信息
Cancer Lett. 2011 Feb 1;301(1):85-94. doi: 10.1016/j.canlet.2010.10.011. Epub 2010 Nov 24.
The present study aimed to evaluate the frequency of KSHV genotypes isolated from Kaposi sarcoma (KS) lesions in patients from Brazil. Fifty KS cases were evaluated. The most frequently detected viral genotypes were A (50.0%) and C (48.0%); the B genotype was isolated only in one case (2.0%). Noteworthy, there was a significant predominance of A genotypes in KS lesions from HIV-positive patients, whereas C genotypes were found mostly in the HIV-negative setting. This finding supports the hypothesis that distinct KSHV genotypes have a non-random distribution in KS, which might be attributable to unique biological properties.
本研究旨在评估从巴西患者的卡波济肉瘤（KS）病变中分离出的 KSHV 基因型的频率。评估了 50 例 KS 病例。最常检测到的病毒基因型是 A（50.0%）和 C（48.0%）；B 基因型仅在一例（2.0%）中分离到。值得注意的是，在 HIV 阳性患者的 KS 病变中，A 基因型明显占优势，而 C 基因型主要存在于 HIV 阴性环境中。这一发现支持了这样一种假说，即不同的 KSHV 基因型在 KS 中呈非随机分布，这可能归因于独特的生物学特性。
Zotero 插件