Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Physiol Behav. 2011 Apr 18;103(1):21-4. doi: 10.1016/j.physbeh.2010.11.013. Epub 2010 Nov 24.
Signaling from energy stores provides feedback on overall nutrient availability to influence food intake. Beginning with seminal studies by Woods and colleagues identifying insulin as an adiposity signal, it has become clear that such factors affect food intake by modulating the efficacy of within meal feedback satiety signals. More recent work with leptin has revealed actions of the hormone in modulating the efficacy of multiple gut feedback signals, identified the dorsal hindbrain as a site of signal integration and suggested both local and descending hypothalamic to hindbrain actions in mediating these effects. The original work by Woods and colleagues provided the necessary experimental paradigms for these advances.
能量储存的信号反馈对整体营养供应情况，从而影响食物摄入。从 Woods 及其同事最初的研究确定胰岛素作为肥胖信号开始，人们已经清楚地认识到，这些因素通过调节餐后反馈饱腹感信号的效率来影响食物摄入。最近关于瘦素的研究揭示了该激素在调节多种肠道反馈信号效率方面的作用，确定了背侧后脑作为信号整合的部位，并提出了局部和下行下丘脑到后脑的作用来介导这些效应。Woods 及其同事的最初研究为这些进展提供了必要的实验范例。
