Hourdou M L, Besson F, Michel G
Laboratoire de biochimie microbienne, Université Claude Bernard, Lyon I, Villeurbanne, France.
Can J Microbiol. 1990 Mar;36(3):164-8. doi: 10.1139/m90-029.
Cerulenin, an inhibitor of fatty acid synthesis, inhibits the biosynthesis of iturin by Bacillus subtilis. With a cerulenin concentration of 2 micrograms/mL, 50% inhibition was achieved. At this concentration, cerulenin does not affect growth or total protein synthesis but does inhibit the incorporation of sodium [14C]acetate, [14C]myristic acid, and [14C]asparagine into iturin. Since cerulenin is known to block the condensation of malonyl-CoA subunits in the formation of fatty acids, the inhibition of iturin and beta-amino acid syntheses by cerulenin is discussed in relation with lipid synthesis.
浅蓝菌素是一种脂肪酸合成抑制剂，它能抑制枯草芽孢杆菌合成伊枯草菌素。当浅蓝菌素浓度为2微克/毫升时，可实现50%的抑制率。在此浓度下，浅蓝菌素不影响生长或总蛋白合成，但会抑制[14C]醋酸钠、[14C]肉豆蔻酸和[14C]天冬酰胺掺入伊枯草菌素。由于已知浅蓝菌素会在脂肪酸形成过程中阻断丙二酰辅酶A亚基的缩合反应，因此结合脂质合成对浅蓝菌素抑制伊枯草菌素和β-氨基酸合成的作用进行了讨论。
