Division of Endocrinology, Diabetes, and Metabolism, Pennsylvania State University College of Medicine, Hershey, PA 17033, USA.
Eur J Obstet Gynecol Reprod Biol. 2011 Mar;155(1):49-53. doi: 10.1016/j.ejogrb.2010.10.027. Epub 2010 Nov 26.
To examine changes in brachial artery conductance (BAC) during reactive hyperemia in women with polycystic ovary syndrome (PCOS) compared to controls.
This is a pilot case-control study performed at a single academic medical center. Changes in BAC during reactive hyperemia were evaluated in 31 women with PCOS and 11 healthy control women. Fasting glucose, insulin, lipids and androgen levels were also determined. A mixed-effects model was used to compare the PCOS curve to the control curve for change in BAC from baseline during reactive hyperemia.
Body mass index (BMI) and testosterone levels were significantly increased in the PCOS group compared to controls (P<0.05). In addition, the PCOS group had higher total and LDL cholesterol levels (P=0.05 and 0.09, respectively). Change in BAC from baseline during reactive hyperemia was significantly increased in the PCOS group compared to controls even after adjusting for age, BMI and LDL cholesterol levels (P<0.0001). There were no significant differences between the two groups in age, blood pressure, or fasting glucose or insulin levels.
Brachial artery conductance during reactive hyperemia is significantly increased in women with PCOS compared to controls and may be a novel early indicator of increased cardiovascular risk in women with PCOS.
研究多囊卵巢综合征（PCOS）女性与对照组相比，在反应性充血期间肱动脉传导（BAC）的变化。
这是在单一学术医疗中心进行的一项试点病例对照研究。在 31 名 PCOS 女性和 11 名健康对照组女性中评估了反应性充血期间 BAC 的变化。还测定了空腹血糖、胰岛素、血脂和雄激素水平。使用混合效应模型比较了 PCOS 曲线和对照组曲线在反应性充血期间从基线到 BAC 的变化。
与对照组相比，PCOS 组的体重指数（BMI）和睾酮水平显著升高（P<0.05）。此外，PCOS 组的总胆固醇和 LDL 胆固醇水平也较高（分别为 P=0.05 和 0.09）。即使在调整年龄、BMI 和 LDL 胆固醇水平后，PCOS 组在反应性充血期间从基线到 BAC 的变化仍明显高于对照组（P<0.0001）。两组之间在年龄、血压或空腹血糖或胰岛素水平方面无显著差异。
与对照组相比，PCOS 女性在反应性充血期间的肱动脉传导明显增加，这可能是 PCOS 女性心血管风险增加的一个新的早期指标。
