Department of Psychiatry, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, Taiwan.
Gen Hosp Psychiatry. 2010 Nov-Dec;32(6):647.e7-9. doi: 10.1016/j.genhosppsych.2010.07.001. Epub 2010 Aug 23.
Growing evidence suggests that proinflammatory responses will be a crucial issue for developing neuropsychiatric disorders. Recent clinical trials demonstrated that adjunctive therapy of cyclo-oxygenase (COX)-2 inhibitor was effective for major depression. Here, we present the case of an elderly depressed woman with acute cognitive deficit who was refractory to multiple antidepressants but only responsive to celecoxib, a COX-2 inhibitor, in acute treatment and sustaining remission for a 5-year treatment course. Our finding suggests that a therapeutic effect of celecoxib exists for major depressive disorder comorbid with neurocognitive dysfunction.
越来越多的证据表明，促炎反应将是神经精神疾病发展的一个关键问题。最近的临床试验表明，环氧化酶（COX）-2 抑制剂的辅助治疗对重度抑郁症有效。在这里，我们介绍了一个患有急性认知功能障碍的老年抑郁女性的病例，她对多种抗抑郁药均无反应，但在急性治疗中仅对 COX-2 抑制剂塞来昔布有反应，并在 5 年的治疗过程中保持缓解。我们的发现表明，塞来昔布对伴有神经认知功能障碍的重度抑郁症有治疗作用。
