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本文引用的文献

1
Large-scale blood group genotyping: clinical implications.大规模血型基因分型:临床意义。
Br J Haematol. 2009 Jan;144(1):3-13. doi: 10.1111/j.1365-2141.2008.07285.x. Epub 2008 Oct 30.
2
The use of maternal plasma for prenatal RhD blood group genotyping.利用孕妇血浆进行产前RhD血型基因分型。
Methods Mol Biol. 2009;496:143-57. doi: 10.1007/978-1-59745-553-4_11.
3
Fetal blood group genotyping.胎儿血型基因分型。
Transfusion. 2007 Jul;47(1 Suppl):64S-8S. doi: 10.1111/j.1537-2995.2007.01313.x.
4
Molecular genetic blood group typing by the use of PCR-SSP technique.运用聚合酶链反应-序列特异性引物(PCR-SSP)技术进行分子遗传血型分型。
Transfusion. 2007 Jul;47(1 Suppl):54S-9S. doi: 10.1111/j.1537-2995.2007.01311.x.
5
Large scale blood group genotyping.大规模血型基因分型。
Transfus Clin Biol. 2007 May;14(1):10-5. doi: 10.1016/j.tracli.2007.04.011. Epub 2007 May 23.
6
Partial D and weak D: can they be distinguished?部分D型和弱D型:它们能被区分开吗?
Transfus Med. 2007 Apr;17(2):145-6. doi: 10.1111/j.1365-3148.2006.00707.x.
7
Molecular characterization of GYPB and RH in donors in the American Rare Donor Program.美国稀有供体计划中供体的GYPB和RH分子特征分析。
Immunohematology. 2006;22(3):143-7.
8
Molecular testing for transfusion medicine.输血医学的分子检测
Curr Opin Hematol. 2006 Nov;13(6):471-5. doi: 10.1097/01.moh.0000245695.77758.3d.
9
The D category VI type 4 allele is prevalent in the Spanish population.D类VI型4等位基因在西班牙人群中很普遍。
Transfusion. 2006 Apr;46(4):616-23. doi: 10.1111/j.1537-2995.2006.00762.x.
10
A comprehensive analysis of DEL types: partial DEL individuals are prone to anti-D alloimmunization.DEL血型类型的综合分析:部分DEL个体易发生抗-D同种免疫。
Transfusion. 2005 Oct;45(10):1561-7. doi: 10.1111/j.1537-2995.2005.00584.x.

欧盟血液基因组计划,2003 - 2009年

The Bloodgen Project of the European Union, 2003-2009.

作者信息

Avent Neil D, Martinez Antonio, Flegel Willy A, Olsson Martin L, Scott Marion L, Nogués Núria, Písăcka Martin, Daniels Geoff L, Muñiz-Diaz Eduardo, Madgett Tracey E, Storry Jill R, Beiboer Sigrid, Maaskant-van Wijk Petra M, von Zabern Inge, Jiménez Elisa, Tejedor Diego, López Monica, Camacho Emma, Cheroutre Goedele, Hacker Anita, Jinoch Pavel, Svobodova Irena, van der Schoot Ellen, de Haas Masja

机构信息

Centre for Research in Biomedicine and Bristol Genomics Research Institute, Faculty of Applied Sciences, University of the West of England, Bristol, UK.

出版信息

Transfus Med Hemother. 2009;36(3):162-167. doi: 10.1159/000218192. Epub 2009 May 28.

DOI:10.1159/000218192
PMID:21113258
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2980524/
Abstract

The Bloodgen project was funded by the European Commission between 2003 and 2006, and involved academic blood centres, universities, and Progenika Biopharma S.A., a commercial supplier of genotyping platforms that incorporate glass arrays. The project has led to the development of a commercially available product, BLOODchip, that can be used to comprehensively genotype an individual for all clinically significant blood groups. The intention of making this system available is that blood services and perhaps even hospital blood banks would be able to obtain extended information concerning the blood group of routine blood donors and vulnerable patient groups. This may be of significant use in the current management of multi-transfused patients who become alloimmunised due to incomplete matching of blood groups. In the future it can be envisaged that better matching of donor-patient blood could be achieved by comprehensive genotyping of every blood donor, especially regular ones. This situation could even be extended to genotyping every individual at birth, which may prove to have significant long-term health economic benefits as it may be coupled with detection of inborn errors of metabolism.

摘要

“血液基因”项目在2003年至2006年期间由欧盟委员会资助,参与机构包括学术血液中心、大学以及Progenika生物制药公司(一家提供包含玻璃芯片阵列的基因分型平台的商业供应商)。该项目促成了一款名为BLOODchip的商用产品的开发,它可用于对个体所有具有临床意义的血型进行全面基因分型。推出这个系统的目的是,血液服务机构乃至医院血库将能够获取有关常规献血者和易感患者群体血型的更多信息。这对于当前因血型不完全匹配而发生同种免疫的多次输血患者的管理可能具有重要意义。未来,可以设想通过对每个献血者,尤其是定期献血者进行全面基因分型,能够实现供体与患者血液的更好匹配。这种情况甚至可以扩展到对每个个体进行出生时的基因分型,这可能会带来显著的长期健康经济效益,因为它可能与先天性代谢缺陷的检测相结合。