Avent Neil D, Martinez Antonio, Flegel Willy A, Olsson Martin L, Scott Marion L, Nogués Núria, Písăcka Martin, Daniels Geoff L, Muñiz-Diaz Eduardo, Madgett Tracey E, Storry Jill R, Beiboer Sigrid, Maaskant-van Wijk Petra M, von Zabern Inge, Jiménez Elisa, Tejedor Diego, López Monica, Camacho Emma, Cheroutre Goedele, Hacker Anita, Jinoch Pavel, Svobodova Irena, van der Schoot Ellen, de Haas Masja
Centre for Research in Biomedicine and Bristol Genomics Research Institute, Faculty of Applied Sciences, University of the West of England, Bristol, UK.
Transfus Med Hemother. 2009;36(3):162-167. doi: 10.1159/000218192. Epub 2009 May 28.
The Bloodgen project was funded by the European Commission between 2003 and 2006, and involved academic blood centres, universities, and Progenika Biopharma S.A., a commercial supplier of genotyping platforms that incorporate glass arrays. The project has led to the development of a commercially available product, BLOODchip, that can be used to comprehensively genotype an individual for all clinically significant blood groups. The intention of making this system available is that blood services and perhaps even hospital blood banks would be able to obtain extended information concerning the blood group of routine blood donors and vulnerable patient groups. This may be of significant use in the current management of multi-transfused patients who become alloimmunised due to incomplete matching of blood groups. In the future it can be envisaged that better matching of donor-patient blood could be achieved by comprehensive genotyping of every blood donor, especially regular ones. This situation could even be extended to genotyping every individual at birth, which may prove to have significant long-term health economic benefits as it may be coupled with detection of inborn errors of metabolism.
“血液基因”项目在2003年至2006年期间由欧盟委员会资助,参与机构包括学术血液中心、大学以及Progenika生物制药公司(一家提供包含玻璃芯片阵列的基因分型平台的商业供应商)。该项目促成了一款名为BLOODchip的商用产品的开发,它可用于对个体所有具有临床意义的血型进行全面基因分型。推出这个系统的目的是,血液服务机构乃至医院血库将能够获取有关常规献血者和易感患者群体血型的更多信息。这对于当前因血型不完全匹配而发生同种免疫的多次输血患者的管理可能具有重要意义。未来,可以设想通过对每个献血者,尤其是定期献血者进行全面基因分型,能够实现供体与患者血液的更好匹配。这种情况甚至可以扩展到对每个个体进行出生时的基因分型,这可能会带来显著的长期健康经济效益,因为它可能与先天性代谢缺陷的检测相结合。