Sforza Daniel M, Löhner Rainald, Putman Christopher, Cebral Juan
Int J Numer Method Biomed Eng. 2010 Oct 1;26(10):1219-1227. doi: 10.1002/cnm.1385.
The effects of parent artery motion on the hemodynamics of basilar tip saccular aneurysms and its potential effect on aneurysm rupture were studied.The aneurysm and parent artery motions in two patients were determined from cine loops of dynamic angiographies. The oscillatory motion amplitude was quantified by registering the frames. Patient-specific computational fluid dynamics (CFD) models of both aneurysms were constructed from 3D rotational angiography images. Two CFD calculations were performed for each patient, corresponding to static and moving models. The motion estimated from the dynamic images was used to move the surface grid points in the moving model. Visualizations from the simulations were compared for wall shear stress (WSS), velocity profiles, and streamlines.In both patients a rigid oscillation of the aneurysm and basilar artery in the anterio-posterior direction was observed and measured. The distribution of WSS was nearly identical between the models of each patient, as well as major intra-aneurysmal flow structures, inflow jets, and regions of impingement.The motion observed in pulsating intracranial vasculature does not have a major impact on intra-aneurysmal hemodynamic variables. Parent artery motion is unlikely to be a risk factor for increased risk of aneurysmal rupture.
研究了母动脉运动对基底动脉尖部囊状动脉瘤血流动力学的影响及其对动脉瘤破裂的潜在影响。通过动态血管造影的电影环确定了两名患者的动脉瘤和母动脉运动。通过配准帧来量化振荡运动幅度。从三维旋转血管造影图像构建了两名患者动脉瘤的个体化计算流体动力学（CFD）模型。对每位患者进行了两次CFD计算，分别对应静态模型和动态模型。从动态图像估计的运动用于移动动态模型中的表面网格点。比较了模拟中的壁面切应力（WSS）、速度剖面和流线的可视化结果。在两名患者中均观察并测量到动脉瘤和基底动脉在前后方向上的刚性振荡。每位患者模型之间的WSS分布几乎相同，以及主要的动脉瘤内血流结构、流入射流和撞击区域。在搏动性颅内血管系统中观察到的运动对动脉瘤内血流动力学变量没有重大影响。母动脉运动不太可能是动脉瘤破裂风险增加的危险因素。
