Spirina L V, Kondakova I V, Choinzonov E L, Sharova N P, Chigevskay S Y, Shishkin D A
Research Institute of Oncology, Siberian Division of Russian Academy of Medical Sciences, Tomsk.
Bull Exp Biol Med. 2010 Jul;149(1):82-5. doi: 10.1007/s10517-010-0881-8.
The development of malignant neoplasm of the head and neck is related to the state of intracellular proteasome system. Elevation of total activity of proteasomes and specific activity of 20S proteasomal pool are accompanied by changes in proteasomal composition. Tumor size correlated with the content of regulatory proteasomal complex PA28. In the presence of regional metastases, 26S proteasome activity decreases and the content of proteasome immune subunit LMP7 in the tumor increases.
头颈部恶性肿瘤的发生与细胞内蛋白酶体系统的状态有关。蛋白酶体总活性的升高以及20S蛋白酶体库的比活性升高伴随着蛋白酶体组成的变化。肿瘤大小与调节性蛋白酶体复合物PA28的含量相关。在存在区域转移的情况下，26S蛋白酶体活性降低，而肿瘤中蛋白酶体免疫亚基LMP7的含量增加。
